In this study, 102 patients with hypertensive intracerebral hemorrhage (52 patients in the citicoline treatment group and 50 patients in the routine treatment group) were analyzed and compared. It was found that citicoline-assisted treatment of hypertensive intracerebral hemorrhage could inhibit the release of serum glial fibrillary acidic protein (GFAP) and peptides ( P < 0.05) and improve the prognosis and neurological and daily living ability of patients ( P < 0.05). In addition, CDP-choline reduced the mortality of neurons, inhibited inflammatory factors, and improved the prognosis of patients ( P < 0.05). A high dose of CDP-choline was also significantly effective in protecting neurons.

Objective: To determine the predictive value of CHA2DS2–VASc score as a predictor for left ventricular thrombus after acute anterior ST-elevation myocardial infarction (STEMI).Methods: We performed a case–control retrospective study of 30 patients with left ventricular thrombus (median age: 60.6 years, range: 38–75 years old; 26 males, 74 females) and 60 age- and sex-matched controls without left ventricular thrombus. Correlation analysis was performed and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of CHA2DS2–VASc score in detecting left ventricular thrombus.Result: Patients with left ventricular thrombus after acute anterior STEMI had higher CHA2DS2–VASc scores than controls (P < 0.001). Correlation analysis revealed that CHA2DS2–VASc scores were positively correlated with left ventricular thrombus after acute anterior STEMI (r = 0.413; P < 0.001). Multiple logistic regression analyses indicated that CHA2DS2–VASc scores (P = 0.001) and heart failure (P = 0.023) were risk factors of left ventricular thrombus. The ROC curve of CHA2DS2–VASc scores revealed that area under curve was 0.746 (95% confidence interval: 0.638–0.853, P < 0.001), sensibility was 86.7%, and specificity was 50.0%.Conclusion: Patients with heart failure have a high incidence of left ventricular thrombus after acute anterior STEMI. CHA2DS2–VASc scores contribute to the prediction for left ventricular thrombus after acute anterior STEMI.

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