No abstract

This study evaluated the dermal cytotoxicity of sodium bromate (NaBrO 3) and the protective effect of Aster tataricus L. (AT) extract against NaBrO 3-induced cytotoxicity in the cultured NIH3T3 fibroblasts. For this study, it was done the antioxidative effects such as electron donating (ED) activity and lipid peroxidation (LP) activity as well as cell viability. NaBrO 3 significantly decreased cell viability in a dose-dependent manner and its XTT 50 value was measured at a concentration of 54.4 μM in these cultures. The cytotoxicity of NaBrO 3 was determined as highly-toxic by Borenfreund and Puerner's toxic criteria. The quercetin, antioxidant significantly increased cell viability against NaBrO 3-induced cytotoxicity. Regarding the protective effect of Aster tataricus (AT) L. extract on NaBrO 3-induced cytotoxicity, AT extract significantly increased the cell viability, the ED ability and the inhibitory ability of LP. From these findings, it suggested that the oxidative stress is involved in the cytotoxicity of NaBrO 3 , and AT extract effectively protected NaBrO 3-induced cytotoxicity by antioxidative effects. Conclusively, the natural component like AT extract may be a putative therapeutic agent for the diminution or treatment of the cytotoxicity correlated with oxidative stress like hair dye component, NaBrO 3 .