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Compatibilty of Bricef Dry Syrup (cefatrizine oral suspension) with mixed solutions which were often pre scribed in our hospital was investigated in terms of changes in external appearance pH and residual potency of cefatrizine (CFT). These changes were checked immediately after and 1, 3, 5, 7 and 14 days after mixing. The results showed lowering, to some extent, of CFT potency in relatively high pH region. Especially, when dry syrup was mxed with an alkaline solution, CFT potency reduced significantly within 24 hours at room temperature. These results suggest that careful attention should be paid to the above combination since a risk of incompatibility may be involved.Color of suspensions of a few preparations changed during the storage. The change in color should be avoided to prevent anxiety in patients, though its correlation with stability of CFT is not clear. In combiantions with other solutions, the change in appearance, pH and potency of CFT was small, suggesting that such combinations be clinically recommendable.

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The disinfection efficacy of superoxidized water on hands, floors and working tables was examined. Superoxidized water was produced by the electrolysis of water. An agar sausage method was empoloyed to compare superoxidized water, 0.2% benzalkonium chloride in ethanol lotion (BAC-EtOH), and 0.3% triclosan with respect to the bacterial elimination effect on the resident flora of the hands (14 subjects). The mean reductions (%) of bacteria after disinfection were 86.5% for superoxidized water, 96.5% for BAC-EtOH, and 37.1% for triclosan, with the difference between superoxidized water and BAC-EtOH treatment not being statistically significant in terms of the reduction (%).However, handborne bacteria were eliminated more effectively with superoxidized water than with triclosan after scrubbing. Furthermore, the disinfection efficacy of superoxidized water was examined on the unused parenteral bottles returned from the general wards.The bottles were disinfected for 5 min with superoxidized water resulting in complete inhibition of bacterial survival.Bacterial surface contamination of floors and working tables was measured by standard agar method for total bacteria and mannitol salt oxacillin agar method for oxacillin-resistant Staphylococci. Following the disinfection with superoxidized water, the mean reductions (%) of bacteria on floors and tables were estimated as being 86.7-100% for total bacteria and 100% for oxacillin-resistant Staphylococci. These results suggest that superoxidized water might be useful for disinfecting the hands and environment in hospital practice.