Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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Abstract. The Global Navigation Satellite System (GNSS) Occultation Sounder (GNOS) is one of the new-generation payloads on board the Chinese FengYun 3 (FY-3) series of operational meteorological satellites for sounding the Earth's neutral atmosphere and ionosphere. FY-3C GNOS, on board the FY-3 series C satellite launched in September 2013, was designed to acquire setting and rising radio occultation (RO) data by using GNSS signals from both the Chinese BeiDou Navigation Satellite System (BDS) and the US Global Positioning System (GPS). So far, the GNOS measurements and atmospheric and ionospheric data products have been validated and evaluated and then been used for atmosphere- and ionosphere-related scientific applications. This paper reviews the FY-3C GNOS instrument, RO data processing, data quality evaluation, and preliminary research applications according to the state-of-the-art status of the FY-3C GNOS mission and related publications. The reviewed data validation and application results demonstrate that the FY-3C GNOS mission can provide accurate and precise atmospheric and ionospheric GNSS (i.e., GPS and BDS) RO profiles for numerical weather prediction (NWP), global climate monitoring (GCM), and space weather research (SWR). The performance of the FY-3C GNOS product quality evaluation and scientific applications establishes confidence that the GNOS data from the series of FY-3 satellites will provide important contributions to NWP, GCM, and SWR scientific communities.