CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular phagocytosis by macrophages, determines life span of individual erythrocytes, regulates activation of immune cells, and manipulates synaptic pruning during neuronal development. As such, CD47 has recently be regarded as one of novel innate checkpoint receptor targets for cancer immunotherapy. In this review, we will discuss increasing awareness about the diverse functions of CD47 and its role in immune system homeostasis. Then, we will discuss its potential therapeutic roles against cancer and outlines, the possible future research directions of CD47- based therapeutics against cancer.
In recent years, distributed power generation has made great progress, but it is still restricted by factors such as low marketlization, lagging public services, and incomplete management systems. This paper studies the trading mechanism of distributed power participation in the market. First, it studies the participation of aggregated distributed power generation resources in the power market; then based on the model of distributed power generation resources that participating in the market through aggregated agents based on this article, the market mechanism is designed.Finally, a calculation example is adopted and the proposed method is verified.
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