Background. The relationship between acne and depression is being actively studied by the medical community. Question is depression a restriction in prescribing or a side effect when using systemic isotretinoin remains controversial. Noteworthy is the presence in the scientific literature of data on the possible positive effect of adequately and timely prescribed acne therapy on the psychoemotional state of patients with this ailment. Aims. The aim of our study was to evaluate the effectiveness of therapy with systemic isotretinoin in patients with moderate and severe acne, to assess the effect of the therapy on the quality of life of patients, as well as the persistence of remission after the end of the course of therapy with systemic retinoid. Methods. We observed 32 patients with moderate and severe acne, the average age of patients was 24 years, the duration of the disease was on average 8 years. All patients underwent therapy with systemic isotretinoin (Sotret) at an average daily dose of 0.51.0 mg/kg until a cumulative dose of 120150 mg/kg was reached. The effectiveness and tolerability of the therapy was assessed, as well as the quality of life of patients was assessed using the dermatological index of the quality of life (DQL), the dermatological akne index (DIA), the HADS scale (anxiety and depression scale). The indicators were assessed before the start of therapy, during therapy, at the end of the course of treatment with systemic isotretinoin, and also 12 months after the end of therapy. Results. 100% of patients achieved clinical remission as a result of treatment with systemic isotretinoin. Before starting therapy with systemic isotretinoin, the indices were as follows: DQL 18 (1520), HADS 10 (716) and DIA 13 (615) scores. By the end of the therapy, the indices decreased to 1 (01), 2 (04) and 1 (01) points, respectively (p 0.001). 12 months (year) after the end of therapy with systemic isotretinoin, the indices remained at zero or one level in all patients: DQL 1 (01), HADS 0 (01) and CIA 1 (01) points (p 0.001). Conclusion. A causal relationship between the intake of systemic isotretinoin and the development of depression has not been established. Systemic isotretinoin therapy was effective in all patients (100%), was well tolerated and had a positive effect on the psychoemotional status of patients with acne. 12 months after the end of therapy with the drug Erase, stable remission of the disease was noted in all patients

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Background. The postacne symptom complex occurs in the outcome of vulgar acne in 40% of cases. Recently, there has been a tendency to grow up acne. Currently, there are many methods in the arsenal of a dermatologist and a cosmetologist for correcting post-acne elements, but most of the procedures for correcting postacne elements have age restrictions, some of the procedures are accompanied by severe pain and the presence of a rehabilitation period, and the economic component of these procedures is also of great importance. Therefore, for the treatment of the post-acne symptom complex, there should be methods that are highly effective and accessible to patients. In most cases, the assessment of the clinical effectiveness of treatment is subjective, both for the doctor and for the patient. Photo documentation is also not in all cases a reliable way to represent the quality and effectiveness of treatment. Consequently, the use of hardware methods for quantifying the severity of disease indicators to confirm the effectiveness of treatment increases the patient's compliance. Aims. Evaluation of the effectiveness of Postacnetin gel in the treatment of postacne symptom complex, using the ANTERA 3D device. Materials and methods. 12 patients aged 18 to 28 years with the presence of postacne symptoms were under observation. The study was conducted on the basis of the Department of Dermatovenereology of SibSMU and the medical center Estetik in Tomsk. During the entire study period, patients applied Postacnetin gel to one half of the face. Treatment regimen: Postaknetin gel was applied in a thin layer, point-by-point on the postakne elements 2 times a day. The duration of treatment was 28 days. To assess the clinical effectiveness, photo documentation, three-dimensional analysis of the skin surface on the ANTERA 3D device and statistical analysis were performed. Results. The average level of redness in 12 patients on the side of using Postacnetin gel before the study was 117.200 0.424, 1 month after using the gel, there was a significant decrease in the level of the indicator to 95.900 0.849 (р 0.05). The average value of the pigmentation level before using the Postacnetin gel and 1 month after use was 56.950 0.919 and 46.600 0.424, respectively (р 0.05). This indicates a significant decrease in the level of pigmentation. The average value of the volume index before the study was 9.350 0.212, after 28 days the volume index decreased to 6.750 0.071, respectively (р 0.05). Conclusions. As a result of the conducted research, it was established with the help of the ANTERA 3D device that the use of Postacne gel for 28 days leads to a regression of the indicators of postacne elements.