No abstract

Acute undifferentiated leukemias (AUL) is the diagnosis of exclusion and is very rare, the morphology of leukemic cells is not specific. Here we report a rare case of AUL with myelofibrosis with an unusual morphology. A 40 year female presented with anaemia and hepatosple enomegaly with pancytopenia and leucoerythroblastic blood picture on peripheral blood smear underwent bone marrow studies. Bone marrow biopsy showed infiltration of blasts with scant cytoplasm, round to irregular nucleus, dispersed chromatin with grade 3 fibrosis by Reticulin stain and negative Masson trichrome stain. Immunohistochemistry (IHC) on bone marrow biopsy showed CD 34 positivity and negative for Tdt, MPO, CD3, CD20, CD61 markers. Thus diagnosed as Acute undifferentiated leukemia with myelofibrosis. AUL is the diagnosis of exclusion and before categorizing leukemia as undifferentiated, it is necessary to perform immunophenotyping with a comprehensive panel of monoclonal antibodies.

BACKGROUND Abnormal Uterine Bleeding (AUB) is the most common presenting symptom in Gynaecology outpatient department. Endometrial sampling could be effectively used as the first diagnostic step in abnormal uterine bleeding in perimenopausal age group. This study was done to evaluate histopathology of endometrium for identifying the endometrial causes of AUB in perimenopausal age.The main objective of the present study is to evaluate the histopathology of endometrium and to identify the hyperplasia of endometrium or endometrial carcinoma. MATERIALS AND METHODSThe present study was conducted in the Department of Obstetrics and Gynaecology, King George Hospital, Visakhapatnam who presented with abnormal uterine bleeding for a period of one year, i.e. March 2015 to March 2016 in the age group of 40 to 55 years. Endometrial tissue is obtained by dilatation and curettage or endometrial biopsy or fractional curettage sent to pathology and histopathology of endometrium evaluated. A total of 200 patients are taken into the present study and histopathology of endometrium obtained and evaluated. RESULTSThe most common histopathology of endometrium is proliferative endometrium followed by secretory endometrium. Simple hyperplasia is observed in 3.5% of patients. Simple hyperplasia with atypia in 0.5%. Complex hyperplasia with atypia observed in 0.5% of patients. CONCLUSIONThe histopathology of endometrium plays a key role in evaluation and further management of abnormal uterine bleeding.