Pelvic organ prolapse describes the loss of support and subsequent descent of pelvic organs into the vagina. It is common, affecting up to 50% of parous women, and can be accompanied by a number of burdening symptoms. Prolapse has been thrown into the spotlight secondary to mesh-related complications. There are a number of effective treatment options to consider when managing pelvic organ prolapse and most do not require mesh. Patients’ choice, comorbidities and likelihood of treatment success should be considered when making decisions about their care. Vaginal mesh surgery is currently on hold in the UK and even prior to this there has been a reduction both in the number of all prolapse surgeries and the number of women seeking surgery to manage their symptoms. This article reviews the current evidence for the management of pelvic organ prolapse, providing an update on the current state of mesh in prolapse surgery and summarises the key evidence points derived from the literature.
iiche mykocide Wirkungen entfalkk. Niihere Angaben iiber die Physiologie und Biologie dieser Bildungen werden in den aMykol. Untersuchungen und Berichtencc1) demnachst erscheinen. Es zeigte sich, dal3 die Krystalle organischer Natur sind, sich in alkalihalligeni Wasser Iosen, und durch Destillntion mit Wasserdanipf in reineni Zustand nahezu quantitativ aus dein Kultursubstrat gewonnen werden koriiieii. Damit war die Moglichkeit gegeben, geniigende Mengeri zur AufklBrung ihi-er Konstitution rein zu g e w i m n , die Prof. W e d e k i n d z ) fmundlichst iibernommen und gemeinsam mit Priv.-Doz. Dr. F1 e is c h e r durchgefiihrt hat. Sie schlagen fur diesen neuen Korper mit der von ihnen bestimmten Konstitution den Namen sparas as sol^ vor. Im Lnufe der Zeit gelang es, den Gehalt der Rohrcheu an Sparassol soweit anzureichern, da13 aus 100 g Agar-Nahrsubstanz (enthaltend 5 g Malzextra!d und 1.50/,, Agar-Agar) in 8 Monaten 0.1 g Sparassol-Ausheute ziemlicli regelma13ig gewonnen wurde. Das Malzextrakt e n t h d t 33 o/o Wasser, ini wasserfreien Extrakt 64 O/o Maltose (mit F e h 1 i n g scher Losung bestimmt), 0.8 O/" Stickstoff und 42 O//o Kohlenstoff. 2 ) Mit L i e b c r 111 a 11 11 s Reagens gab Sparassol lteine Farhenreaktion, eine Eigenschafl, dic bei p-substituierten Phenolen beobaclitet worden ist (vergl. 11. M e y c r , Konstilutionserniittlung organ. Substanzen, 3. Aufl., S. 483). 3) B e r z i g und W e n z e l , M. 24, 896, 899 [1903]. Beridite d. D. Chem. Gesellschaft. Jahrg. LVI. 165
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