No abstract

Psychiatrists need more information about the children of their patients and about the general possibilities of prevention as well as more knowledge of supportive offers of the youth welfare.

The cross-linking of structural proteins is critical for establishing the mechanical stability of the epithelial compartments of the skin and skin appendages. The introduction of isopeptide bonds between glutamine and lysine residues depends on catalysis by transglutaminases and represents the main protein cross-linking mechanism besides the formation of disulfide bonds. Here, we used a fluorescent labeling protocol to localize the activity of transglutaminases on thin sections of the integument and its appendages in mammals and birds. In human tissues, transglutaminase activity was detected in the granular layer of the epidermis, suprabasal layers of the gingival epithelium, the duct of sweat glands, hair follicles and the nail matrix. In the skin appendages of chickens, transglutaminase activity was present in the claw matrix, the feather follicle sheath, the feather sheath and in differentiating keratinocytes of feather barb ridges. During chicken embryogenesis, active transglutaminase was found in the cornifying epidermis, the periderm and the subperiderm. Transglutaminase activity was also detected in the filiform papillae on the tongue of mice and in conical papillae on the tongue of chickens. In summary, our study reveals that transglutaminase activities are widely distributed in integumentary structures and suggests that transglutamination contributes to the cornification of hard skin appendages such as nails and feathers.

Psychic disorders were studied with a naturalistic design in 125 consecutive patients of a medical-geriatric department in a general hospital. Based on the clinical examination and the values of the Mini-Mental-State-Examination (2), 51 patients were classified as unable for diagnostic procedures concerning psychic state. The other 74 patients underwent these diagnostic procedures including clinical investigation and three screening-scales (Geriatric Depression Scale (11); Hospital Anxiety and Depression-Scale (4)). If these examinations led to the suspicion that a patient suffered from a psychic disorder, an interview was performed by a psychotherapist with experience in gerontopsychosomatic treatment and information was collected from the medical and nursing staff. Dementia was detected or excluded by neuropsychological tests. Psychic disorders were found in 41 patients, mostly adaptation disorders and depressions. In more than half of the patients, the disorder was estimated to be relevant for the whole hospital therapy. The screening instruments turned out to be reliable, so they can be recommended for further use. Difficult to answer remains the question, how the treatment of the psychic disorders--in our sample necessary for each 5th to 6th patient--can be implemented in a medical-geriatric department.