Background:Preeclampsia complicates 10% of pregnancies in the developed world. Alteration in angiogenic factors occurs in preeclampsia which leads to chronic hypoxic changes in placenta.Aim:To assess the histomorphological changes and expression of angiogenic factors in placenta of preeclamptic patients in comparison to normal placenta.Design: Cross sectional analytical study.Materials& Methods: This study was conducted from October 2013 to August 2015 and included 53 placenta from preeclamptic patients and 53 placenta from healthy pregnant women. Histomorphological changes were studied in the placenta. Expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) in the placental villi were evaluated using immunohistochemistry (IHC).Statistical analysis: Done using IBM-SPSS 21.0. ‘p’ value < 0.05 was taken as significant.Results: In our study, 92.5% of preeclamptic group were in the age group of 21 to 34 years and 62.3% of them had placental weight of less than 500 grams.

Spindle cell lesions of breast pose diverse morphological patterns which can turn out to be reactive, benign and malignant tumours with overlapping features. Differential diagnosis are wide. It is challenging to the pathologist due to its rarity. The origin of spindle cell lesions of the breast is highly variable and represents multiple lineages. Hereby authors report a case of a 56-year-old female presented to the Outpatient Department with left breast swelling. Mammogram showed hypoechoic ill-defined irregular lesion. On imaging findings, evolving abcess and neoplastic were consider probable diagnosis. On histopathological examination, the lesion showed bland spindle cells arranged in short fascicles and and in diffuse pattern. The lesion was diagnosed as spindle cell lesion. Immunohistochemistry confirmed the diagnosis of fibromatosis. The standard treatment of wide local excision with adequate safety margins was done. Postoperative period was uneventful. On two years follow-up, the patient had no recurrence. While being very rare at this site, the lesion has locally aggressive behaviour with high recurrence rate.

Aim:We report an uncommon case of uterine inflammatory myofibroblastic tumor (IMT), a unique mesenchymal tumor often misdiagnosed as "fibroid uterus" on radiology. Background: Inflammatory myofibroblastic tumor is a mesenchymal tumor reported in the lungs, mesentery, omentum, and retroperitoneum. Its occurrence in the uterus is rare and is often misidentified as a smooth muscle or endometrial stromal tumor. Herein, we report a case of IMT of the uterus. Case description: A 33-year-old lady presented to the OP with menorrhagia. USG abdomen was reported as bulky uterus with an intra-mural (8.7 × 7 cm) fibroid arising from the anterior myometrium. No lymph nodes or free fluid noted. "Myomectomy" was done under spinal anesthesia, and the specimen was sent for HPE. Grossly, it was a circumscribed gray-white soft-tissue mass mimicking a leiomyoma. However, microscopy of the mass was rather unusual to call it a leiomyoma. It had a "tissue-culture-like" or "nodular fasciitis-like" appearance. There were spindle cells in fascicles and prominent myxoid change with lymphoplasmacytic infiltrate. No nuclear atypia, necrosis, or infiltrative margins were noted. So, a morphological diagnosis of IMT was made. Conclusion:The case is reported for its diagnostic challenge and rarity. Clinical significance: Inflammatory myofibroblastic tumors are uncommon mesenchymal tumors of low malignant potential with a tendency to recur and rare metastases. Surgical excision is the treatment of choice. Recurrent IMTs can be treated with ALK-based targeted therapy.