Aggressive lymphoma of non-Hodgkin’s type is uncommon. The most common clinical presentation is lymphadenopathy and fever. One-fifth of Non-Hodgkin’s Lymphoma (NHL) present with serous effusions involves the body cavities like pleural, abdominal and pericardial cavities. Ten percent of aggressive lymphomas occur without an underlying immunosuppressive status. The NHL is more common in the elderly with a male preponderance. Paraneoplastic syndromes are rarely associated with non-Hodgkin’s lymphoma. Peritoneal lymphomatosis is extremely rare and associated with a poor prognosis. Since clinical suspicion for underlying malignancy is higher with peritoneal carcinomatosis (than for serous effusion of body cavities), they get recognised early. However, peritoneal lymphomatosis can be neglected and misdiagnosed. This series is about five cases of aggressive non-Hodgkin’s lymphoma. These cases are presented here for their rarity and diverse clinical manifestations. The case of angioimmunoblastic lymphoma was seen in an elderly male who presented with hypoglycaemia serous effusion and lymphadenopathy. Two patients were diagnosed with Natural Killer (NK) cell lymphoma and they presented with serous effusion with a jejunal thickening, as visible in the CT scan. One case of Diffuse Large B Cell Lymphoma (DLBCL) was seen in an elderly female presenting with inguinal lymphadenopathy. Lymphoma shows a varied clinical and radiological presentation and it should always be a differential diagnosis in the massive serous effusion and unexplained bowel thickening in Computed Tomography (CT) imaging with or without lymphadenopathy. The cases reported here emphasise the importance of early pathological diagnosis and immunohistochemical confirmation to ensure that the right treatment can be started at an appropriate time.

Spindle cell lesions of breast pose diverse morphological patterns which can turn out to be reactive, benign and malignant tumours with overlapping features. Differential diagnosis are wide. It is challenging to the pathologist due to its rarity. The origin of spindle cell lesions of the breast is highly variable and represents multiple lineages. Hereby authors report a case of a 56-year-old female presented to the Outpatient Department with left breast swelling. Mammogram showed hypoechoic ill-defined irregular lesion. On imaging findings, evolving abcess and neoplastic were consider probable diagnosis. On histopathological examination, the lesion showed bland spindle cells arranged in short fascicles and and in diffuse pattern. The lesion was diagnosed as spindle cell lesion. Immunohistochemistry confirmed the diagnosis of fibromatosis. The standard treatment of wide local excision with adequate safety margins was done. Postoperative period was uneventful. On two years follow-up, the patient had no recurrence. While being very rare at this site, the lesion has locally aggressive behaviour with high recurrence rate.