Abstract:The title compounds (4a,b) were prepared by chloroacetylation of 2-acyl-3-aminobenzofuran(1a,b) and subsequent treatment with hexamethylene tetramine in ethanol via the complex salts (3a,b). Similar reaction with ethyl 3-aminobenzofuran-2 carboxylate (5) produced 3H-benzofuro[3,2-e]-1,4-diazepin2,5(1H,4H)-dione (7) in good yield. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial and anticonvulsant activities.

Present work reports the biologically important benzofuran aryl ureas and carbamates. The benzofuran ring was formed by reacting bromo salicylaldehyde with diethyl bromomalonate in presence of dry acetone and anhydrous potassium carbonate to obtain 5-bromo-2-ethyl carboxylate (1). The obtained ester (1) was converted into corresponding hydrazide (2) by treating with hydrazine hydrate in ethanol. Compound 2 was then converted into 5-bromobenzofuran-2-carbonyl azide (3) by treating it with sodium nitrite in dioxane and acetic acid. The compound 3 is converted into 5-bromobenzofuranyl aryl ureas (4a-e) after treating primary amines and anhydrous toluene. 5-Bromobenzofuranyl aryl carbamate (5) and ethyl carbamate (6) were also synthesized by treating compound 3 with substituted phenol in toluene and ethanol respectively. All the compounds were characterized by NMR, IR and screened for antimicrobial activities.

Aus dem Benzofurancarbonsäureester (Ia) werden über das Hydrazid (Ib) die Thiosemicarbazide (Ic) hergestellt, die zu den Triazolen (II) bzw. den Thiadiazolen (III) cyclisiert werden.

A series of benzofuran derivatives compounds have been designed and synthesized. Here, Benzofuran linked with pyridinone compounds is reported. The desired compounds were prepared by using 2-nitrosalisaldehydnitrile (1). After, this is treated with chloroacetone, which results in the formation of 1-(3-amino-5-nitro-1-benzofuran-2-yl) ethanone (2). Later the 3a-b is produced by a reaction of acetylation and benzylation on compound 2 respectively. The alkylation of compounds 4a-b react with sodium hydroxide, we get new pyridinone compounds. All the synthesized compounds were characterized by IR, 1H NMR, and GCM. Further, these have been screened for their antimicrobial, and antioxidant activity. Along with this activity reference we design drug discovery of Molecular docking study by using different computational software.