Background: Pain and inflammation are disabling accompaniments of many medical conditions. So, controlling both pain and inflammation assumes the top priority for the physician. Inflammation is a part of a complex biological response of vascular tissues to harmful stimuli such as pathogens, chemicals or irritants. Therapy of pain and inflammation has always been debatable. Methods: Rats were divided into 8 groups of 6 animals of each. The antiinflammatory activity was studied with carrageenan induced rat paw edema and cotton pellet induced granuloma models. The analgesic activity was evaluated using Eddy's hot plate model. The aqueous extract of Rubia cardifolia root and Cassia fistula leaf preparations were compared with Diclofenac in both acute and sub acute inflammatory models and also in pain model. Results: Various test result parameters were statistically analysed at P value <0.5. In Eddy's hot plate model both RC and CF preparations prolonged the response reaction time, while CF preparation showed longer reaction time than that of RC preparation. In carrageenan induced paw edema and cotton pellet induced granuloma models, both RC and CF preparations showed significant decrease in paw edema volume and granuloma dry weight respectively, but less than that of Diclofenac. RC preparation found to have dose dependant in inflammatory models. Conclusions: RC root and CF leaf preparations were compared head to head and they have been found to have significant dose dependant analgesic activity and dose independent acute and sub acute anti inflammatory activities. Though CF leaf preparation appeared to be a good analgesic than RF root preparation, but failed to do so as an anti inflammatory agent in both inflammatory models. But both test preparations were not equivalent to Diclofenac in all three models.

Background: Diabetes Mellitus (DM) is a global epidemic and a leading cause for increased mortality and morbidity. The prevalence of Diabetes is very high so the management of DM and its complication like diabetic ketoacidosis (DKA) is very crucial in today’s world. Medical students being the future pillars of our health care system were included in this study to know their knowledge towards diabetes and its acute complication DKA.Methods: This study was a questionnaire based observational study conducted in Adichunchanagiri Institute of Medical Sciences, B G Nagara. Final year medical students and interns were included in the study.Results: A total of 150 (75 from each group) questionnaires were collected and analysed. Most of the final year students and interns were aware about the classical symptoms of diabetes (73.33% and 84% respectively) and were aware about the endocrine gland related to diabetes (82.6% and 94.6% respectively) however there were differences about the meaning of PPBS among both the groups. Interns (76%) had better knowledge regarding the fluid replacement in the management of DKA in compared to final year students (41.33%). There was statistically significant difference in knowledge between the two groups regarding GDM.Conclusions: This study identifies that both final year students and interns need to improve the practical knowledge towards diagnostic parameters of DM and treatment of DKA. Continous medical education programmes and workshops should be organised to enhance the knowledge towards DM and its complications.