Limited reciprocal pharmacokinetic interaction between milnacipran and CYP isoenzymes would confer flexibility in the therapeutic use of the drug when combined with antidepressants. Drug-drug interaction risk would be low, even if the combined treatments were likely to inhibit CYP2D6 and CYP2C19 isoenzyme activities.
The hydrocarbon fractions of the essential oils from leaves of Cistus ladanifer, C. palhinhae, C. laurifolius and C. monspeliensis were analysed by GLC and GCMS techniques.
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