Plant Based Natural Products (PBNPs) have been subject of interest since ancient time due to their use in food, industrial and biomedical applications. Research attention has further augmented to explore their phytochemical composition, properties, and potential application in the post-COVID era. In the present study phytochemical screening has been carried out with Methanolic Leaf Extracts of Moringa oleifera (MLEMO) followed by Gas Chromatography-Mass Spectrometry (GCMS) analysis. Phytochemical analysis of MLEMO revealed the presence of Alkaloids, Carbohydrates, Coumarins, Flavonoids, Glycosides, Phenol, Proteins, Quinones, Saponins, Steroids, Tannins and Terpenoids. Further, GCMS analysis revealed the presence of 41 compounds of which Dihydroxyacetone; Monomethyl malonate; 4H-Pyran-4-one,2,3-dihydro-3,5-dihydroxy-6-methyl; 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl); Propanoic acid, 2-methyl-, octyl ester; 3-Deoxy-d-mannoic lactone; Sorbitol; Inositol; Cyclohexanemethanol, alpha-methyl-4-(1-methylethyl), Hexadecanoic acid, Methyl palmitate; n-Hexadecanoic acid (Palmitic acid); 9-Octadecenoic acid, methyl ester; Phytol; 9,12,15-Octadecatrienoic acid; Octadecanoic acid; 9-Octadecenamide were prominent. Most of the compounds in the list are bioactive and possess medicinal properties that are expected to serve as a baseline lead for the development of therapeutic agents. Keywords: Phytochemical screening; GCMS; Bioactive Natural Products; Moringa oleifera; MLEMO; Biomedical application

9,12,15-Octadecatrienoic acid (ODA) a carboxylic acid composed of 18 carbon atoms and three cis double bonds. ODA is a plant derived essential fatty acid indispensable to the human system. ODA refers to many different structural and conformational isomers, that differ in the position of the double bonds along the backbone and on whether they are in cis ('Z') or trans ('E') conformation. It has been well established that ODA can only be outsourced from food and then converted into eicosa-pentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) in the human system. However, this metabolic process is highly limited and the rate of conversion is influenced by several factors such as dose, gender, and disease. Studies suggest that ODA is associated with reduced risk of fatal ischemic heart disease. Further, higher intake may reduce the risk of sudden death among prevalent myocardial infarction in patients consistent with induced antiarrhythmic effect. ODA significantly reduces blood clots. Traditional usage of ODA is attributed to its cardiovascular-protective, anti-cancer, neuro-protective, anti-osteoporotic, anti-inflammatory, and anti-oxidative properties. Recent pharmacological indicate that ODA has anti-metabolic syndrome, anticancer, anti-inflammatory, anti-oxidant, anti-obesity, neuro-protective, and more specifically involved in the regulation of gut-micro-floral functionalities. Studies, both experimental and clinical trials indicate that ODA has anti-metabolic syndrome effects. In short, ODA is potentially used to treat many diseases, but in-depth ADMET studies are required to firmly re-establish its clinical efficacy and market potential. Keywords: ADMET; Moringa oleifera; Secondary Metabolites; Natural Products (NPs); Bioactive Substances; Octadecatrienoic acid (ODA); Eicosa-Pentaenoic Acid (EPA); Docosa-Hexaenoic Acid (DHA)