ISBN du colloque : 978-1-59593-627-1System-level design methodologies have been introduced as a solution to handle the design complexity of embedded multiprocessor SoC (MPSoC) systems. In this paper we describe a system-level design flow starting from Simulink specification, focusing on concurrent hardware and software design and verification at four different abstraction levels: Simulink Combined Algorithm and Architecture Model (CAAM), Virtual Architecture, Transaction-accurate Model and Virtual Prototype. We used two multimedia applications, Motion-JPEG and H.264, to evaluate this design flow. Experimental results show that our design flow can generate various MPSoC architectures from Simulink CAAM correctly and efficiently, allowing processor and task design space exploration at different abstraction levels