Both medical and surgical treatment can be used to achieve long-term survival of dogs with CPSS, although results of statistical analysis supported the widely held belief that surgery is preferable to medical treatment. However, the study population consisted of dogs at referral clinics, which suggested that efficacy of medical treatment may have been underestimated. Although surgical intervention was associated with a better chance of long-term survival, medical management provided an acceptable first-line option. Age at examination did not affect survival, which implied that early surgical intervention was not essential. Dogs with CPSS that do not achieve acceptable resolution with medical treatment can subsequently be treated surgically.

Effects of different ageing methods on colour, yield, oxidation and sensory qualities of Australian beef loins consumed in Australia and Japan

Selection for increased lean meat yield using Australian Sheep Breeding Values for reduced post-weaning c-site fat depth (PFAT) and increased post-weaning eye muscle depth (PEMD) reduces the oxidative capacity of muscle. Isocitrate dehydrogenase (ICDH) activity and myoglobin concentration were measured in 3178 and 5580 lambs, respectively, to indicate oxidative capacity. In the progeny of sires with a reduced PFAT, ICDH activity and myoglobin concentration were reduced by 0.46 μmol/min/g tissue and 0.67 mg/g tissue across the 5 and 6mm PFAT ranges respectively. In the progeny of sires with an increased PEMD, ICDH activity and myoglobin concentration were reduced by 0.50 μmol/min/g tissue and 0.49 mg/g tissue across the 7 and 6 mm PEMD ranges respectively. However, the sites at which the lambs were raised had a larger impact on oxidative capacity than genetic or other production factors.

No abstract

The thymus is innervated by sympathetic/parasympathetic nerve fibers from the peripheral nervous system (PNS), suggesting a neural regulation of thymic function including T-cell development. Despite some published studies, data on the innervation and nerve-immune interaction inside the thymus remain limited. In the present study, we used immunofluorescent staining of glial fibrillary acidic protein (GFAP) coupled with confocal microscopy/three-dimensional (3D) reconstruction to reveal the distribution of non-myelinating Schwann cells (NMSC) and their interactions with immune cells inside mouse thymus. Our results demonstrate (1) the presence of an extensive network of NMSC processes in all compartments of the thymus including the capsule, subcapsular region, cortex, cortico-medullary junction, and medulla; (2) close associations/interactions of NMSC processes with blood vessels, indicating the neural control of blood flow inside the thymus; (3) the close "synapse-like" association of NMSC processes with various subsets of dendritic cells (DC; e.g., B220 DCs, CD4 DCs, and CD8 DCs), and lymphocytes (B cells, CD4/CD8 thymocytes). Our novel findings concerning the distribution of NMSCs and the associations of NMSCs and immune cells inside mouse thymus should help us understand the anatomical basis and the mechanisms through which the PNS affects T-cell development and thymic endocrine function in health and disease.