Метою роботи є вивчення антигельмінтної активності та гострої токсичності препарату, що містить альбендазол та празиквантел у співвідношенні (1: 4) щодо збудників аскаридозу у свиней, токсокарозу та дипілідіозу у собак. Ці патогени належать до класу нематодозів (аскаридозу, токсокороз) та цестодозів (дипілідіозу). Матеріали та методи. Дослідження проводили у копроскопічній лабораторії кафедри паразитології ХДЗВА за стандартизованим методом Фюллеборна і «Способом кількісного визначення яєць гельмінтів» (патент № 9265). Зразки для дослідження на собаках були отримані в КП "Центр поводження з тваринами". Для вивчення ступеня токсичності запропонованої комбінації альбендазолу і празиквантелу у поросят відбирали проби крові перед прийомом препарату та через 24 год і 72 год після початку лікування для проведення морфологічних і біохімічних досліджень. Результати. Отримані результати свідчать про наявність антигельмінтної активності досліджуваного препарату по відношенню до збудників аскаридозу, токсокарозу та дипілідіозу. Показники гематологічних досліджень у свиней вільних від кишкових гельмінтів до та через 24 і 72 год після прийому препарату знаходились у межах фізіологічної норми. Результати клінічного обстеження тварин обох дослідних груп показали, що поведінка тварин не змінилася (природня), прийом корму і води в н ормі, видимі слизові оболонки -блідо-рожевого кольору, шкірний покрив -цілісний, без пошкоджень, шкіра еластична. Висновки. Таким чином, запропонований препарат демонструє високий рівень антигельмінтної активності щодо збудників аскаридозу, токсокарозу та дипілідіозу. Ступінь його токсичності відповідає показнику «малотоксичний». Отримані результати вказують на доцільність подальших досліджень

The aim of the research was to investigate the rheological behaviour of hydroxyethyl cellulose gels, which are used in the development of the composition and technology of the medicine with anti-inflammatory activity. The objects of research were hydroxyethyl cellulose gels in the concentration of 1.0%; 1.5%; 2.0%; 2.5% and 3.0%. Investigation of the rheological behavior of HEC gels (structural and mechanical properties) was performed using the Rheolab QC rheometer from Anton Paar (Austria) using the C-CC27 / SS Coaxial Cylinder System. The obtained results showed that excipients influence on the rheological behaviour in the following way: propylene glycol and polyethylene oxide 400 reduce rheoparameters, while PEG 40 hydrogenated castor oil increases these parameters. The further study of the rheological properties in comparison with medicines “Troxerutin” and “Thiotriazolinum” showed that the developed gel fully corresponds to technological and consumer requirements.

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The aim of the work was to obtain essential oil from the leaves and flowers of the genus Hawthorn Crataegus monogyna L. and study its component composition to justify the possibility of expanding the use of this herbal drugs in medicine. Materials and methods. The leaves and flowers of Сrataegus monogyna L., which were used to obtain essential oil, were harvested in the western region of Ukraine in 2019. The quantitative content of essential oil in the herbal drugs was determined by hydrodistillation. By used chromato-mass spectrometry method determined the component composition of essential oil of leaves and flowers of Сrataegus monogyna L. The obtained spectra were compared with the library of mass spectra NIST05 and WILEY 2007 with a total number of spectra over 470000 in combination with programs for identification AMDIS and NIST.Results. The essential oil of leaves and flowers of Сrataegus monogyna L. was obtained and its quantitative content was determined, which was 0.15±0.02 % for flowers and 0.11±0.03 % for leaves. By used chromato-mass spectrometric method in the essential oil of flowers of Сrataegus monogyna L. revealed 37 compounds, leaves – 33. In the essential oil of flowers found monoterpenoids, the content of which was 0.44 % of the total, triterpenoids 7.17 %, aromatic compounds 12.61 %. In the essential oil of leaves were found monoterpenoids 37.8 %, aromatic compounds 10.25 %, norterpenoids 3.62 %, sesquiterpenoids 4.02 %, diterpenoids 2.17 %, triterpenoids 5.08 %.Conclusions. Due to the defined component composition of the essential oil of flowers and leaves of Сrataegus monogyna L., we consider its use to create drugs of external action for the treatment of skin diseases of various etiologies caused by staphylococcal and fungal microflora.

The existing range of medicines is represented by a variety of dosage forms. Among them a significant proportion takes oral solid dosage forms, in particular capsules. The introduction of active pharmaceutical ingredients in the capsule composition does not require the addition of flavouring agents and requires a significantly lower amount of excipients compared to the formation of tablet dosage forms. In the development of dosage forms based on extracts of medicinal plants, the rational choice of the dosage form is important. The use of capsules allows making a composition of several extracts, providing the proper consumer characteristics of the finished product. The aim of the workis to study methodological approaches to the development of the drug «Phytohelmin», proposed for use in the 3rd phase of the treatment of helminthiasis of the digestive system. As the objects of research scientific works of domestic and foreign authors, databases and own findingswere selected. When conducting the own research, we used methods of bibliosemantic analysis, systematization and generalization of data. Capsules are characterized as a dosage form: the definition, classification, features, advantages and disadvantages are presented. When developing a medicine for the treatment of helminthiases of the digestive system in phase III (eliminating the consequences of the disease and restoring the functions of the gastrointestinal tract), we selected the solid capsule dosage form. We present a decision tree for 6 stages of choosing the medicinal plant material to justify the capsule composition under the conditional name «Phytohelmin». 7 Degrees of the general algorithm for pharmaceutical development of capsules are described and solutions for each stage directly for the capsules of the proposed composition are given. Based on the results obtained, the main methodological approaches to the development of drugs in the form of capsules are formulated, in particular, capsule characteristics and classification are given, and the advantages and disadvantages of this dosage form are analyzed. The tree of decisions on the choice of medicinal plant materials in the development of medicines and the final composition of the capsules «Phytohelmin», obtained on the basis of its application, is given. The general algorithm for the pharmaceutical development of capsules and the corresponding solutions for the development of «Phytohelmin» capsules based on it in accordance with the requirements of Guide 42-3.1: 2004 «Quality Guide. Medications. Pharmaceutical Development» is described.