Cervical insufficiency (CI) is one of the main pathological conditions that leads to pregnancy loss, in particular, recurrence miscarriages and premature births, which account for up to 5 % of all obstetric cases. Recurrence pregnancy losses caused by CI lead to serious psychological trauma for both the woman and her family members, as well as significant economic losses for the society. However, many women in some regions of the world still do not know about this pathology, and clinicians do not always diagnose this condition in time.At the same time, etiology of CI remains uncertain, and there are still ambiguous points regarding the diagnosis of this pathology and its treatment. The diagnosis of CI should be established by analyzing the medical history, clinical manifestations and results of ultrasound examination. Treatment of CI mainly includes surgical and conservative methods. Surgical treatment is performed with cervical cerclage, while conservative techniques mainly include the use of vaginal progesterone and insertion of various types cervical pessaries. This article summarizes the potential risk factors associated with cervical insufficiency that are of great attention and may be useful for future researches. Also, the review of the literature considers modern methods of diagnosis and treatment of CI to understand this pathology of the cervix better. From a modern standpoint, a consensus and problematic issues are presented in accordance with the recently updated recommendations, which are of practical importance, and are also important for further deeper research on this topical issue of modern obstetrics.

The article presents a review of the current literature on the problem of uterine leiomyoma (UL) in women of reproductive age during pregnancy and childbirth. We studied the main issues of uterine leiomyoma etiology and pathogenesis, as one of the leading causes of reproductive dysfunction and possible complications during pregnancy and childbirth.UL is the most common tumor of the female genitalia and occurs in 20–30% of women of reproductive age. It is impossible to determine a more accurate indicator of this pathology, given the asymptomatic course of more than 70% of cases and irregular consultations by obstetricians and gynecologists.There is evidence that uterine leiomyoma is associated with infertility in only 5–10% of cases, but only 2–3% of cases when all other causes are ruled out. The submucosal node has the most adverse effect on fertility and reduces the implantation frequency by 72% and increases the miscarriage risk by 60%. Subserous LM affects fertility to a lesser extent than submucosal LM, but large nodules can lead to infertility requiring surgical treatment. An individual approach to the treatment of women with intramural LM is required, as there is insufficient data on the node effect on fertility.The most common complications of pregnancy, childbirth and the postpartum period in women with uterine leiomyoma in 22–58% of cases are late preeclampsia, fetoplacental insufficiency, anemia of pregnancy, fetal growth restriction, incorrect position and presentation of the fetus. Pregnancy also adversely affects UL, leading to acute secondary changes and rapid tumor growth, which in turn can lead to severe obstetric complications.

According to the WHO, neoplastic processes of the uterus remain one of the important and relevant areas of modern gynecology. Uterine leiomyoma is one of the most common tumors of the female reproductive system. According to the latest data, every 4–5th woman in the world is diagnosed with leiomyoma, the incidence of which under the age of 35 reaches 50%, and according to autopsy data reaches 80%.The article provides a review of the scientific publications in recent years devoted to the study of the problem of uterine fibroids – relevance, causes and mechanisms of development, provides a classification, clinical manifestations, modern diagnostics and management tactics.The etiological factors of leiomyoma are numerous, there is no a single theory of the disease. Among the pathogenetic factors of leiomyoma are hormonal disorders, genetic components, infections, injuries. There are several classifications of leiomyoma, the most common classification was proposed by the International Federation of Gynecology and Obstetrics, which reflects the types of leiomatous nodes depending on their location and relationship to the uterine cavity and myometrium.Clinical manifestations of uterine fibroids range from asymptomatic to painful sighns and hemorrhagic syndromes, symptoms of compression of adjacent organs, the development of uterine bleeding, which lead to severe anemia. The nature of clinical features significantly depend on the localization of the leiomyoma nodes in the uterine body and their relationship to the uterine cavity (submucosal, intramural, subserous), as well as their number, size and blood supply.Modern diagnosis of leiomyoma is based on anamnesis, bimanual gynecological examination, ultrasound examination, and in some cases – magnetic resonance imaging and computed tomography examinations, hysteroscopy and laparoscopy. Today, the main methods of treatment of leiomyoma are conservative, surgical and radiological methods (uterine artery embolization, magnetic resonance-guided focused ultrasound).In addition to the listed modern aspects of the clinic, diagnosis and treatment of uterine leiomyoma, the article emphasizes the importance of preventive measures to reduce the incidence of this gynecological pathology.

The increase in the frequency of cesarean section (CS) remains one of the actual problems of modern obstetrics and causes the concern to the world community. Today, it is believed that the abdominal delivery is a safer and more non-traumatic method of delivery for the benefit of the fetus than vaginal delivery. The relative number of cases of abdominal delivery, according to the WHO, should not exceed 10 % of the total number of births, which minimizes the occurrence of complications and prevents the development of bleeding and purulent-inflammatory diseases in the postpartum period. But the latest data demonstrate that this percentage is 18.6 % worldwide, that is one in five births ends in CS. The frequency of CS has been growing rapidly in recent years in most countries of the world, and in this context Ukraine is no exception (14.2 % in 2006, to 25.08 % in 2020). This increases the risk of maternal and perinatal morbidity and mortality. In the presented material for the distance learning about the operative delivery, doctors will find up-to-date information on indications, contraindications, methods of CS, as well as recommendations on counseling of pregnant women before surgery and preventive measures to minimize complications during obstetric surgery. According to the modern approach, the indications for the CS are divided into planned and urgent ones, which are clearly defined in this article. Considerable attention is paid to counseling of the patients before this operation and the obligatory acquaintance of the pregnant woman with the method of performing CS, anesthesia and potential perioperative complications and signing her the informed consent on the possible expansion of surgery. According to the standpoint of evidence-based medicine, the most optimal method of CS is presented, which significantly reduces the likelihood of hemorrhagic, purulent-inflammatory complications during surgery and in the postoperative period. The issues related to modern methods of anesthesia of CS with the use of multimodal analgesia, early mobilization of women in labor and prevention of thromboembolic complications, rehabilitation measures are also identified.

The article presents a clinical case of nodular uterine leiomyoma of giant size on the background of type 2 diabetes mellitus, chronic hypertension and obesity with a classic picture of metabolic syndrome and the development of severe vascular pathology with steno-occlusive atherosclerotic lesions of the abdominal aorta bifurcation (Lerich’s syndrome) and acute circulatory disorders in the left lower extremity with gangrene of the toes of the left foot. The patient was hospitalized and comprehensively examined in the Department of Vascular Surgery of the Kyiv Regional Clinical Hospital (KRCH), which is the clinical base of the Department of Obstetrics and Gynecology №1 of the Shupyk National Healthcare University of Ukraine. The diagnosis was confirmed in the department and simultaneous two-stage surgery was successfully performed by gynecologists and vascular surgeons: first stage – pangysterectomy with revision of the abdominal organs and access to the abdominal aorta, second stage – thrombendarterectomy of the bifurcation of the abdominal aorta. In the postoperative period we restored peripheral blood flow, performed complete regression of ischemia, necrosis of the toes of the left foot dry, limited with a tendency to delimitation. Amputation of the first and second toes of the left foot was performed. Postoperative period was uneventful, on day 9 the patient was discharged home in satisfactory condition for further outpatient treatment. Diabetes mellitus type 2, chronic hypertension and obesity with a classic clinical picture of metabolic syndrome have led to the development of uterine leiomyoma and atherosclerotic changes in the abdominal aorta and main vessels of the lower extremities (Lerich’s syndrome). The successful outcome of this clinical case was made possible by the coordinated work of a multidisciplinary team of KRCH specialists both at the stage of comprehensive examination and diagnosis, and during simultaneous surgery.