No abstract

No abstract

: Bronchial asthma is one of the most common and severe disease among children. The phenomenon of creatinuria (CU) in patients with bronchial asthma (BA) has been acknowledged for relatively long time. : Aim of the research is to study the level of creatinuria, creatinemia, creatine kinase activity and the concentration of calcium in biological medium (blood, saliva, urine) in children suffering from intermittent and persistent form of asthma during the period of exacerbation. Material and methods:: The research consists of 102 children’s with asthma who were treated in inpatient department in Simferopol Clinic. The intermittent course of asthma was recorded in 49 children and persistent course of asthma was recorded in 53 children. The subject of study was blood serum and daily urine of observed patients. The level of calcium in the biological medium was studied using the "Filisit" test kit (Dnipropetrovsk) and the activity of the creatine kinase by test set "Lahma". The levels of creatine and creatinine were determined using a calorimetric method based on a color reaction with picric acid. Results and conclusion: : The analysis testifies that creatinuria in children with persistent BA is caused by the disorder of the phosphorylation process rather than the disorder of creatinin rephospholiration synthesis, that is testified by the normal creatinin level. In children with persistent BA, there is а decrease of creatinin concentration in the blood serum and urine during the exacerbation period and early post exacerbation period. The low activity of creatinin kinase at the background of creatinine elimination is typical for the children in the phase of exacerbation of persistent form of BA, though its level remains to be sufficient for the synthesis of the necessary amount of creatinin phosphate. The processes of creatinuria and calciuria in children suffering from persistent form of BA are interdependent, that is testified by the data of correlative analysis. In connection with this it is possible to consider the change of calcium homeostasis in pathogenesis of the disease as one of the causes of distributing the creatinin metabolism on the cellular level.

A retrospective multicenter chart review was conducted with the objective of evaluating the hypothesis that certain cases diagnosed as tension-type headache (TTH) in pediatric neurology are not stress-related or central sensitization-related conditions but may mimic an autoimmune disorder of the dura mater. Of the 29,642 patient charts reviewed, 12,424 charts (42%) were excluded because of incomplete data and 17,218 cases were analyzed. For all the 29,642 charts, TTH or chronic daily headaches were diagnosed in 29.2% of cases. Among the 17,218 cases subjected to detailed diagnostic procedures, TTH was diagnosed in only 5%. In 7,044 cases, the initial diagnosis of TTH was changed to headache attributed to infection (87.4%), which was supported by the presence of meningeal signs, high antistreptolysin-O titers, and, in 46% of cases, magnetic resonance imaging (MRI)-detected thickening of the cranial dura mater. The initial diagnosis of migraine was confirmed in 87.7% of cases (8,034/9,162). In some cases of treatment-resistant pediatric recurrent headaches, which are initially diagnosed as TTH, a secondary type of headache may be suspected as the underlying cause. Usually this type of headache has streptococcal infection-related laboratory findings, the meninges as the site of the lesion, and meningism as the clinical presentation.

BACKGROUND: We investigated adolescents' feelings of thermal comfort during the educational process in various geographical locations far apart and present recommendations for the adjustment of the thermal environment in schools. METHODS: The prospective international multicenter study took place in 8 locations on different continents. The survey in the form of a questionnaire was carried out among 2800 healthy high school students. The study was divided into ''cold season survey,'' ''warm-season survey,'' and heat wave survey. RESULTS: The statistically significant difference between the ''cold season survey'' score of 4.04 (discomfort) and ''warm-season survey'' score of 3.47 (slight discomfort) (p = .04) indicates that students feel more thermal discomfort during winter months in all 8 locations. The heat wave survey score was 4.53 (discomfort). During the cold season, 29.24% of high school students felt themselves in full thermal comfort and 76.48% of the students felt themselves relatively comfortable (slightly cool-comfortable-slightly warm). CONCLUSIONS: Even during the ongoing process of climate change, the cold season discomfort remains the main problem for students in classes. This tendency is present in different continents as a universal problem. We recommend keeping an entrance hall and classroom temperatures at different levels and to advise students about proper clothing.