No abstract

The medicinal recipe composed of Parquetina nigrescens (Periplocaceae) and Erythrina senegalensis (Fabaceae) is a remedy used in traditional medicine in Côte d'Ivoire to treat diabetes. this study aims to assess the potential anti-diabetic effect of the drug recipe (RPNES) and its effect on the lipid profile and hemoglobin glycation in diabetic rats. Diabetes mellitus is induced by an intraperitoneal injection of streptozotocin, dissolved in a citrate buffer solution, at a dose of 65 mg/kg BW and a nicotinamide solution at a dose of 230 mg/kg BW to Wistar rats. Healthy rats and diabetic rats are treated orally with RPNES daily for 28 days and blood samples from control and treated rats are taken for assay of biochemical parameters. This study shows that RPNES, administered at doses greater than or equal to 600 mg/kg BW, causes a significant decrease in blood sugar in diabetic rats. in addition, a significant decrease in serum total cholesterol and triglyceride levels, associated with an increase in serum HDL cholesterol level, was observed in diabetic rats which received RPNES at 800 mg/kg BW, after 28 days treatment. In addition, after 90 days of treatment, RPNES (800 mg/kg BW) induces a significant decrease in the percentage of glycated hemoglobin in diabetic rats. This study also revealed that, in diabetic rats, RPNES had antihyperglycemic and antidiabetic effects similar to those of glibenclamide. RPNES is also a hypolipemic substance which corrects lipid disorders associated with diabetes, normalizes HDL cholesterol and lowers HbA1c levels in diabetic rats. These results justify the use in traditional medicine of this medicinal recipe composed of Parquetina nigrescens and Erythrina senegalensis to treat diabetes.

In Africa, particularly in Côte d'Ivoire, Solanum torvum (Solanaceae) is commonly used in traditional medicine for the treatment of several pathologies, including diarrhea. In order to contribute to the promotion of medicinal plants by establishing scientific bases justifying their uses in traditional medicine, this study is conducted on Solanum torvum (Solanaceae). Diarrhea is a deadly disease, considered by WHO to be a public health problem. The aim of this study is mainly to assess, in rats, the antidiarrheal potential of an aqueous extract of Solanum torvum leaves (EASt). For this, rats are pretreated with EASt before receiving castor oil by mouth, then their diarrheal droppings are counted. Their gut is isolated and emptied to determine the volume of intestinal contents. The duration of intestinal transit is also measured using activated charcoal used as a marker. This study shows that, in / kg bw dose-dependent reduced the appearance and the number of droppings of diarrhea and, thus, reduced the severity diarrhea. In these rats, EASt also causes a decrease in the volume of intestinal contents and a reduction in intestinal mobility compared to the diarrheal controls. These effects of EASt are similar to those of loperamide on diarrheal droppings and on the volume of the intestinal contents of rats rendered diarrheal. These effects are also similar to that of atropine sulfate on the gastrointestinal mobility of rats with diarrhea. These EASt actions indicate that this extract has anti-diarrheal properties. These anti-diarrheal properties of the aqueous extract of Solanum torvum justify the traditional use of this plant against diarrhea. This extract could therefore be recommended in the treatment of this pathology.

Background: Many medicinal plants including Spondias mombin L are used in traditional medicine for treatment of many pathology. It is therefore used for rational for remedies derived from medicinal plants. Aim: As part of concerning traditional medecine drugs, a toxicology study was conducted on the stem bark of Spondias mombin L., remedy used to treating of diarrhea. Materials and method: Total aqueous extract of the stem bark of this plant was orally administered at one dose of 2000 and 5000 mg/kg body weight to two (2) batches of five (5) female rats during fourteen (14) days. Five (5) female rats control group consisting received distilled water. All the animals were sacrificed after treatment, their blood and nutritional organs such as (liver and kidneys) were removed. Results: This study showed no death was observed between the animals, however clinical signs were notified through the observation time. Indeed, the LD50 is therefore greater than 5000 mg/kg of body weight. In addition, hematological parameters analysis shows a significant increase of erythrocyte and leucocyte cells but not significant for thrombocyte cells. Therefore, it was observed, the weight of liver and kidneys significant increase. Conclusion: Stem bark of Spondias mombin L is a power immunostimulator which could justify is using of traditional medicine traitment for pathology.