In Africa, particularly in Côte d'Ivoire, Solanum torvum (Solanaceae) is commonly used in traditional medicine for the treatment of several pathologies, including diarrhea. In order to contribute to the promotion of medicinal plants by establishing scientific bases justifying their uses in traditional medicine, this study is conducted on Solanum torvum (Solanaceae). Diarrhea is a deadly disease, considered by WHO to be a public health problem. The aim of this study is mainly to assess, in rats, the antidiarrheal potential of an aqueous extract of Solanum torvum leaves (EASt). For this, rats are pretreated with EASt before receiving castor oil by mouth, then their diarrheal droppings are counted. Their gut is isolated and emptied to determine the volume of intestinal contents. The duration of intestinal transit is also measured using activated charcoal used as a marker. This study shows that, in / kg bw dose-dependent reduced the appearance and the number of droppings of diarrhea and, thus, reduced the severity diarrhea. In these rats, EASt also causes a decrease in the volume of intestinal contents and a reduction in intestinal mobility compared to the diarrheal controls. These effects of EASt are similar to those of loperamide on diarrheal droppings and on the volume of the intestinal contents of rats rendered diarrheal. These effects are also similar to that of atropine sulfate on the gastrointestinal mobility of rats with diarrhea. These EASt actions indicate that this extract has anti-diarrheal properties. These anti-diarrheal properties of the aqueous extract of Solanum torvum justify the traditional use of this plant against diarrhea. This extract could therefore be recommended in the treatment of this pathology.
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