Zinc-containing hydroxyapatite particles (Zn/HAp) were prepared by an ion exchange reaction process involving hydroxyapatite (HAp) particles with aqueous solutions containing various amounts of zinc nitrate. The Zn 21 ion was partially substituted for the Ca 21 ion position in the HAp lattice, and hence, the obtained samples had changed little in crystallinity, particle size, and specific surface area. Adsorption of bovine serum albumin (BSA) and b 2 -microglobulin (b 2 -MG) in solutions containing both BSA and b 2 -MG was examined. As the Zn 21 ion content in the apatites increased, the adsorbed amount of BSA was almost constant, whereas that of b 2 -MG increased.

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Nano-crystalline Mg-containing hydroxyapatite (Mg·HAp) were prepared by a wet chemical method, for which selective adsorption of proteins was examined, taking bovine serum albumin (BSA) and a pathogenic protein β2-microglobulin (β2-MG) as the model proteins. Increase in the Mg content led to smaller crystallites and larger specific surface area (SA) of Mg·HAps as well as zeta potential, while the amount both of BSA and β2-MG adsorption on Mg·HAp particles. It is thus concluded that the adsorption of BSA and β2-MG on Mg•HAp was associated with surface charges.

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