Hutchinson‐Gilford Progeria syndrome, also known as Progeria, is a rare genetic disorder, caused by LMNA gene mutation resulting in segmental aging syndrome. It affects one in 20 million people worldwide and has an estimated prevalence of one in four million. It has no sex predilection and affects all races. The syndrome does not manifest signs and symptoms until 9 to 12 months of life and the life expectancy is often only until age 12 to 16 years old (Mayo Clinic, 2016). The purpose of the study was to peruse the available research and to disseminate information to the public in order to increase awareness of the syndrome, and to rectify any misconceptions about the disorder. Using a systematic review of literature, the findings suggested that a multi‐disciplinary approach is needed to help the affected children increase their quality of life.Edilberto A. Raynes, MD, PhD; Kelly Glymph, SPT; Keshia Agazuma, SPT; Lauren Waller, SPT; Karen Coker, PT, DPT, CWS, C/NDT, FACCWS; Natalie Michaels, PT, EdD, GCS Emeritus, and Imelda Banting, PT, MD

A relationship between bone density and prosthetic use exists among all individuals with lower limb amputations. The selection of suspension in prosthetic design and distal limb weight bearing affect the non‐density of the residual limb. The aim of the study was to identify the factors that impact positive bone remineralization in children with through knee amputation.A systematic review of peer reviewed journals of physical therapy interventions, prosthetic socket and suspension design, and through knee amputations in children was done. Eighteen articles met the inclusion criteria. Bone mineral density loss after an amputation surgery is typical but the extent of loss can be minimized by the multifocal approach of physical therapy with gait training, properly fitting prosthetics with weight‐bearing designs.Physical therapists are crucial to this approach with assessment and training in mobility and gait, especially in children with post amputation. The through knee amputation allows for increased weight bearing as well as the skin fit suspension and socket design. By weight bearing remineralization of lost bone in the residual limb is possible in the patient with through knee amputation.Support or Funding InformationNo funding sources were used.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

The purpose of the study is to review the epidemiological aspects of the dengue fever infection. The infection is caused by dengue viruses (DENV), which have four different serotypes and antigenically distinct. The DENV is transmitted by a vectorborne day biting mosquito, Aedes agypti. The clinical spectrum ranges from dengue fever to dengue hemorrhagic fever. Based on our review from the World Health Organization, Centers for Diseases Control and Prevention, as well as from other studies, the disease is still more endemic in the Southeast Asia and Western Pacific regions with an estimate of 300 million infections annually, mostly affecting children. Factors that contribute to the emergence of DENV infection worldwide include substandard living conditions, virus evolution, lack of vector control programs, and international travelers. The best measure of DENV control is prevention by increasing awareness of the public through coordinated outreach programs to the community coordinated by various stakeholders. There are still no available vaccines and specific medications to cure. A multidisciplinary collaboration needs to be mobilized to combat the vector.Support or Funding InformationNoneThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.