Background and Purpose: The Magnetic Resonance Arthrogram (MRA) has served as the gold standard for identifying patients with possible Superior Labrum Anterior-Posterior (SLAP) lesions and are often required by orthopaedic surgeons prior to clinical evaluation. However, as the literature shows MRA sensitivity as 0.65-0.98, and specificity between 0.80-1.00, there is still room for misinterpretation of the imaging study, and potential mismanagement of a patient who may or may not exhibit a true SLAP lesion. It is proposed that by grouping a series of clinical special tests it may be possible to develop greater sensitivity in identifying a SLAP lesion, resulting in the ability to better manage this patient population, thus avoiding unnecessary and costly imaging studies and decreased referrals to surgical specialists. The purpose of this study is to examine specific combinations of SLAP lesion special tests and identify which clusters of tests have the highest sensitivity and specificities. This may allow therapists to improve the management of their patients by reliably diagnosing a SLAP lesion and referring only those who may need surgery to a physician. Study Design: Literature review, diagnostic sensitivity/specificity outcomes Methods: A retrospective search of the current peer-reviewed literature was performed in an effort to identify the clinical special tests with the greatest sensitivity and specificity in identifying SLAP lesions. Based upon that search, the study was limited to five special tests: Biceps Load I, Biceps Load II, Speed's, Passive Compression, and O'Brien's tests. A multiple regression analysis was performed that looked at grouping of the tests to determine the diagnostic sensitivity/specificity when grouped. Results: Obtaining positive results on three of the five special tests resulted in a sensitivity of 0.992-0.999 and a specificity of 0.992-0.999. The combination of the Biceps Load I/II and O'Brien's showed the highest sensitivity and specificity. Conclusion: The results indicate that a combination of at least three positive SLAP lesion tests may be clinically useful in diagnosing a shoulder SLAP lesion with greater diagnostic accuracy than those reported for MRI/MRA, thus improving patient management by referring only those who may require surgical intervention to a physician.

The consumption of energy drinks has recently become a popular practice among athletes and college students. Research has shown the inappropriate use of energy drinks can increase the risk for cardiovascular complications. The objective of this study was to explore on the knowledge, attitudes and practices on the use of energy drinks among 137 Division I athletes. A cross sectional study design was utilized with an online survey questionnaire. In terms of attitudes, 77% of the participants did not use energy drinks with alcohol and did not mix with other substances and 19% consumed energy drinks to enhance sports performance. In terms of practices, more than 80% of the participants did not use energy drinks during sports activity and rarely consumed it monthly. Based on the results, the participants appear knowledgeable on the appropriate use of energy drinks.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

Hutchinson‐Gilford Progeria syndrome, also known as Progeria, is a rare genetic disorder, caused by LMNA gene mutation resulting in segmental aging syndrome. It affects one in 20 million people worldwide and has an estimated prevalence of one in four million. It has no sex predilection and affects all races. The syndrome does not manifest signs and symptoms until 9 to 12 months of life and the life expectancy is often only until age 12 to 16 years old (Mayo Clinic, 2016). The purpose of the study was to peruse the available research and to disseminate information to the public in order to increase awareness of the syndrome, and to rectify any misconceptions about the disorder. Using a systematic review of literature, the findings suggested that a multi‐disciplinary approach is needed to help the affected children increase their quality of life.Edilberto A. Raynes, MD, PhD; Kelly Glymph, SPT; Keshia Agazuma, SPT; Lauren Waller, SPT; Karen Coker, PT, DPT, CWS, C/NDT, FACCWS; Natalie Michaels, PT, EdD, GCS Emeritus, and Imelda Banting, PT, MD

The purpose of the study is to review the epidemiological aspects of the dengue fever infection. The infection is caused by dengue viruses (DENV), which have four different serotypes and antigenically distinct. The DENV is transmitted by a vectorborne day biting mosquito, Aedes agypti. The clinical spectrum ranges from dengue fever to dengue hemorrhagic fever. Based on our review from the World Health Organization, Centers for Diseases Control and Prevention, as well as from other studies, the disease is still more endemic in the Southeast Asia and Western Pacific regions with an estimate of 300 million infections annually, mostly affecting children. Factors that contribute to the emergence of DENV infection worldwide include substandard living conditions, virus evolution, lack of vector control programs, and international travelers. The best measure of DENV control is prevention by increasing awareness of the public through coordinated outreach programs to the community coordinated by various stakeholders. There are still no available vaccines and specific medications to cure. A multidisciplinary collaboration needs to be mobilized to combat the vector.Support or Funding InformationNoneThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.