Eikenella corrodens is a slow-growing, gram-negative, nonmotile, facultative rod that can cause infection in humans. Although the clinical characteristics of Eikenella infections in adults are well described, the literature regarding Eikenella infections in children is lacking. Thirteen cases of Eikenella infection in children and adolescents reported from a hospital and an additional 41 cases from the literature were reviewed. Eikenella species can be serious pediatric pathogens, particularly when there is an exposure to human oral secretions. Empirical therapy used to manage most oropharyngeal flora may be ineffective against Eikenella species. The treatment of choice for children and adolescents who are infected with Eikenella species includes a combination of surgical management and antibiotics.

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Methods. Ten patients with primary hepatocellular carcinoma were treated with intraarterial instillation of yttrium‐90 (Y‐90) microspheres, including eight men and two women (median age, 52 years; range, 29‐69 years). Four patients were treated at a targeted hepatic dose of 50 Gy, two at 75 Gy, and four at 100 Gy. Results. In 8 of the 10 patients, there was a significant concentration of Y‐90 in localized tumor masses with tumor‐to‐liver perfusion ratios from 1.0:1‐10.0:1. No patient had a complete or partial response, but 10 patients had stable disease (median duration, 10 weeks; range, 5‐64 weeks). The median survival was 18 weeks (range, 2‐150 weeks), and three patients lived longer than 1 year. Significant bone marrow or hepatic toxicity was not seen. One patient had a radiation‐induced duodenal ulcer that required surgical management. Conclusions. Intraarterial instillation of Y‐90 microspheres appears to be safe and deserves additional evaluation to determine whether there is meaningful activity in patients with primary hepatocellular carcinoma. Cancer 1992; 70:2250‐2254.