An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.

Data are reviewed from positron e on tomography studies of en ing and retrieval processes in epiodic memory. These data suggest a hpheric encodIng/retrieval asymmetry model of prefontal involvement in encoding and retrieval of episodic memory. According to this model, the left and rit prefrontal lobes are part of an extensive neuronal network that subserves episodic remember-

The study confirms that D(2) occupancy is an important mediator of response and side effects in antipsychotic treatment. The data are consistent with a "target and trigger" hypothesis of antipsychotic action, i.e., that the D(2) receptor specificity of antipsychotics permits them to target discrete neurons and that their antagonist properties trigger within those neurons intracellular changes that ultimately beget antipsychotic response. While limited to haloperidol, the relationship between D(2) occupancy and side effects in this study helps explain many of the observed clinical differences between typical and atypical antipsychotics.

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