This study aimed to analyze the salivary flow of irradiated patients for the head and neck cancer treatment after the conclusion of their treatment, and to compare it to the salivary flow of a group of non-irradiated patients. The salivary flow measurement was performed using the stimulated saliva analysis technique by masticatory action. The data collected were organized in planning using the Microsoft Excel program and then analyzed through the program IBM SPSS 20.0. The independent T-test was used to compare the median values between the groups that had normal distribution. 54 patients were evaluated, 18 from Group 1, of irradiated patients with an average time of ending radiotherapy of 11 months; and 36 patients from Group 2, with non-cancerous and non-irradiated patients. The mean salivary flow of Group 1 patients was 0.39 (± 0.85) and 100% of the patients expelled less than 3.5mL of saliva after stimulation for five minutes. Among the patients from Group 2, the mean salivary flow was 3.22 (± 2.65), and 77.78% of the patients had a salivary stimulation of less than 3.5 mL. This difference was statistically significant (p = 0.004). Through the methodology used, a high prevalence of hyposalivation was observed in patients irradiated in head and neck for cancer treatment even after months of the treatment conclusion and among patients without cancer and not submitted to radiotherapy. However, a deficiency in saliva production was statistically higher among patients irradiated in the head and neck. Keywords: Neoplasms. Radiotherapy. Saliva. Xerostomia. ResumoEste estudo teve como objetivo analisar o fluxo salivar de pacientes irradiados no tratamento do câncer de cabeça e pescoço após a conclusão de seu tratamento, e compará-lo com o fluxo salivar de um grupo de pacientes não irradiados. A medição do fluxo salivar foi realizada utilizando a técnica de análise de saliva estimulada por ação masticatória. Os dados coletados foram organizados no planejamento utilizando o programa Microsoft Excel e, em seguida, analisados através do programa IBM SPSS 20.0. O teste T independente foi utilizado para comparar os valores medianos entre os grupos que apresentaram distribuição normal. Foram avaliados 54 pacientes, 18 do Grupo 1, de pacientes irradiados com tempo médio de término da radioterapia de 11 meses; e 36 pacientes do Grupo 2, com pacientes não cancerosos e não irradiados. O fluxo salivar médio dos pacientes do Grupo 1 foi de 0,39 (± 0,85) e 100% dos pacientes expeliram menos de 3,5 mL de saliva após estimulação por cinco minutos. Entre os pacientes do Grupo 2, o fluxo salivar médio foi de 3,22 (± 2,65), e 77,78% dos pacientes apresentaram estimulação salivar inferior a 3,5 mL. Essa diferença foi estatisticamente significante (p = 0,004). Por meio da metodologia utilizada, observou-se alta prevalência de hiposalivação em pacientes irradiados na cabeça e pescoço para tratamento de câncer mesmo após meses da conclusão do tratamento e entre pacientes sem câncer e não submetidos à radioterapia. No entanto, a deficiência na produção de saliva foi estatisticamente maior entre os pacientes irradiados na cabeça e pescoço. Palavras-chave: Neoplasias. Radioterapia. Saliva. Xerostomia.

Central giant cell lesion (CGCL) is an uncommon alteration of obscure etiology that, although benign, can be highly destructive. This paper presents the case of a patient with CGCL addressing its diagnosis and treatment. An 18-year-old male patient with facial asymmetry due to signifi cant volumetric increase in the right parotidmasseteric and submandibular regions with 9 months of evolution attended the Department of Dentistry of Mato Grosso Cancer Hospital. After clinical and imaginological examinations, an incisional biopsy was performed leading to the diagnostic of CGCL. With the negative results for hyperparathyroidism, the lesion reduction was attempted with corticosteroids infi ltrations. Due to the lesion extension and the lack of response to the infi ltrations, the resection was performed. The patient is in attendance for 2 years without any symptoms of recurrence. Although more prevalent among female, young adults and elderly, the CGCL may present in other patients and the professional must be aware. The therapy of choice in this pathology varies with the aggressiveness and extension of the lesion. More aggressive lesions can lead to more extreme clinical management and involve the need for surgical resection.