The article is devoted to the issues of the features of computer structural modeling of bio- and physiological systems of the human body. It has been established that most of the elements of a living organism and biological processes occurring in them are formalized using integral-differential equations of higher orders, the analytical solution of which is difficult. As modeling components of biotechnical systems and complexes, it is proposed to use circuitry implementation of a wide class of functional solvers based on functional circuits of operational amplifiers, which makes it possible to observe and study the dynamics of parameters of a biological object and bioprocesses in the visual modeling environment in the form of their mathematical models in real time.

The research of the psychophysiological state of winterers of the Antarctic station "Academician Vernadsky" was carried out in order to establish the feasibility of their subsequent stay at the station and fulfill their service tasks. Short-term stay of polar explorers under difficult conditions causes stressful effects and nonspecific adaptive reactions. Their organisms must adapt to the exposure of various extreme factors and, in the first turn, natural ones. Considering that hematopoiesis is an important mechanism on which the ultimate adaptive result depends, a study of blood parameters was performed. It has been found that there are some changes in certain blood parameters that are not relevant with the reference norms for the studied polar groups. In this connection, there is a problem in adjusting the reference intervals for them. In order to determine the reference intervals, it is necessary to take into account the uncertainty of their establishment, having previously analyzed the sources of uncertainty.