S u m m a r y Introduction:The common bean (Phaseolus vulgaris L.) is an annual plant grown in many countries all over the world including its different varieties in Poland. Herbal raw material are elongated pods -pericarp. Phaseoli pericarpium decreases the glucose blood level. Phaseoli pericarpium extracts manifest duretic properties, can be used in the treatment of edema, kidney diseases with decreased urinary excretion, nephrolithiasis. Objectives: To investigate the usefullness of selected excipients as carriers of dry extract from Phaseolus vulgaris pericarp. Methods: The method of direct tableting was used. In the further stage, the obtained tablets were subjected to appropriate tests. The first stage of the study evaluates Prosolv SMCC 50, PROSOLV EASYtab, EMDEX, Carmellose calcium and PRUV. These were used to manufacture 4 batches of tablets. In the second stage, an oral solid dosage was manufactured on the basis of the formulation composition of batch 1 tablets (Phaseoli pericarpium extract, Prosolv SMCC 50, PRUV). Then, different surfactants (cholesterol oxyethylate n TE = 30, cholesterol oxyethylate n TE = 40, Rofam n TE = 50), were successively added to this formulation, to obtain 3 batches of tablets. All 7 batches were manufactured in the Erweka tableting machine. Then, they were subjected to morphological tests and physicochemical evaluation. The release of active substances to 3 selected acceptor fluids (water, artificial gastric juice, artificial intestinal juice) was measured in accordance with the requirements of the general and specific monographs in European Pharmacopoeia 7. Results: The manufactured tablets had a smooth uniform surface with no stains, spalls or mechanical damage and yellow color originating from the extract. The obtained tablets, with surfactants in their com- INTRODUCTIONPhaseolus is a genus of the family Fabaceae including about 200 species of annual and perennial plants, vines and subshrubs with large leaves and white, yellow or red flowers [1]. The common bean (Phaseolus vulgaris L.) belongs to this family. It is an annual plant originating from South America. It is cultivated in many countries, including Poland, for food, dry seeds and immature pods. It exhibits a wide variety of seed coat patterns and colors [2,3].The pharmacopoeic material described in the Polish Pharmacopoeia VI [4] is the dried pericarp (bean pod, Phaseoli pericarpium) derived only from white-flowered cultivars of Phaseolus vulgaris. The pericarps are curled and slightly thin, up to 20 cm long and up to 2 cm wide. One end has a short beak-like point, while a 1 cm stalk is often attached to the other. The outside surface is pale yellow or dark brown yellow, the inside is covered with a whitish, shiny membrane. In the areas where seeds are present, the pericarp is concave inside and convex outside [4].The main pharmacologically active compounds of Phaseoli pericarpium are: choline, amino acids (arginine, asparagine, leucine, lysine), pipecolic acid, trigonelline, allantoin, phenolic acids, mineral ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.