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Background: Recommendations for health care institutions to evaluate the effectiveness of nurse internship programs in facilitating the acquisition of an interprofessional collaborative practice exist. This pilot project explored the effectiveness of simulation-based education compared with online education on inter-professional socialization and collaboration among newly licensed RNs transitioning into medical-surgical practice. Method: An experimental repeated-measures design examined professional nursing practice attributes of values, attitudes, and behaviors along with interprofessional collaboration core competencies. Participants ( n = 29) were randomized into either a control group (nurse internship with online interprofessional education) or an experimental group (nurse internship with simulation-based interprofessional education). Results: Changes in interprofessional role socialization and valuing occurred as measured by the Interprofessional Socialization and Valuing Scale. Interprofessional Collaborative Competency Attainment Survey data demonstrated a change in interprofessional collaboration. Conclusion: Findings support how educators in the health care setting can consider the integration of interprofessional education teaching methodologies into nurse internship programs. [ J Contin Educ Nurs . 2020;51(7):331–337.]