We report calculation results for the transmission characteristics of terahertz hollow fibers with inner coatings of absorptive dielectric and metal layers. The absorption property of the dielectric film has an obvious influence on the transmission property of terahertz hollow fiber, because the optimum thickness of the dielectric layer is several tens of micrometers. Calculations were conducted on the loss properties of the hollow fiber with and without the absorptive dielectric layer. Important results were obtained, such as the optimum refractive index for the absorptive dielectric layer and the absorption tolerances for hollow fibers with various inner diameters.

Immunohistochemical localization of epidermal growth factor receptor (EGFR) in normal salivary glands and tumours (108 cases) was studied using a monoclonal antibody. In the normal salivary glands, EGFR was occasionally detected in ductal segments of intercalated, striated, and excretory ducts, but not in acinar cells. The frequency of positive EGFR staining in salivary gland tumours was not high: pleomorphic adenoma, 33.8%; mucoepidermoid tumour, 25.0%; adenolymphoma, 44.4%; and sialoadenocarcinoma, 66.6%. Pleomorphic adenomas showed positive staining for EGFR on the luminal side of luminal cells and in squamous metaplastic cells of tumour tissue. Some modified myoepithelial cells were also reactive whereas outer spindle tumour cells were unstained. Adenolymphomas regularly exhibited positive EGFR staining in the cell membrane; mucoepidermoid carcinoma displayed positive staining in cell membranes in epidermoid tumour cells and cytoplasmic staining in mucous-secreting tumour cells. Sialocarcinomas revealed cell membrane staining and whole cytoplasmic staining for EGFR. The immunohistochemical localization of EGFR could be classified into two types, one the cell membrane-positive type found in epithelial tumour cells, and the second the cytoplasmic positive type seen in normal ductal cells, the luminal tumour cells of pleomorphic adenomas and mucous-secreting tumour cells.

The penetration depth in water was measured for Er:YAG laser light in a high density relevant to clinical applications. Various types of focusing elements were used to guide the light efficiently. We found that the transmission distance depended strongly on the beam shape in the water. When we used a plano-convex type of focusing cap, the penetration depth was larger than that when a dome- or ball-type cap were used.

An Er:YAG laser light delivery system composed of a polymer-coated silver hollow waveguide and a quartz sealing cap has been developed for calculus fragmentation. Sealing caps with various distal-end geometries were fabricated, and the focusing effects of these caps for Er:YAG laser light were measured both in air and in water. Owing to the high power capability of the quartz a beam of sealing caps, Er:YAG laser light with an output energy of 200 mJ and a repetition rate of 10 Hz was successfully transmitted in saline solution by use of the system. Calculus fragmentation experiments conducted in vitro showed that the delivery system is suitable for medical applications in lithotripsy. We also found that the cap with a focusing effect is more effective in cutting calculi. The deterioration of the sealing caps after calculus fragmentation is also discussed.

Abstract:The modification of mid-infrared radiation spatial profile caused by COP/Ag hollow glass waveguide was investigated. The four laser systems -flashlamp pumped Er:YAG, Tm:YAG, and diode pumped Tm:YAG, and Tm:YAP laser sources -generating radiation in free-running regime were designed and constructed. The cyclic olefin polymer-coated silver hollow glass waveguide having an inner diameter of 700 µm and length up to 1.3 m was used as a delivery system base. The changes of beam spatial structures through the transfer system are presented. For Er:YAG laser the waveguide system was also investigated for bent cases. The energy transmission characteristics were measured for all systems.Output beam spatial structure of Er:YAG laser radiation from 1.3 m long waveguide; 100 mJ energy