The esophagus was totally examined in 264 autopsied cases and 61 operated cases, for a total of 325 cases, to clarify the histogenesis of squamous cell carcinoma of the esophagus. Epithelial dysplasia of the mucosa was present in 27y0 and subclinical carcinoma was found in 2.4%. Hyperplasia of the duct of the esophageal gland proper was present in 34% and dysplasia of the ductal epithelium in 3%. Reserve cell hyperplasia-like change of the islet of the ectopic gastric mucosa was found in 4% and reserve cell hyperplasia-like change of the esophagogastric junction zone in 13%. Of the seven cases of microcarcinoma, two showed dysplasia and gradual transition and one presented dysplasia and abrupt transition. Another two were considered to have originated in the ductal epithelium. These findings suggested that they could all be the sites of origin of cancer development.

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The all lymph nodes and lymphoid tissues of the 15 dead leprosy patients were collected at autopsies and their 603 specimens were histologically investigated.The tissue reactions were devided into 4 types. 1) the change occured chiefly in reticulum and contained migrating simple large cells (large cell type), 2) foamy cells stained with Sudan III and in serious cases diffuse fatty infiltration were observed (foamy type), 3) in which, accomapnied with fatty infiltration, giant vacuoles suggestive of fatty masses and giant cells of foreign bodies were recognized (fat accumulating type) and 4) which produced necrosis (necrosed type).In macular and neural leprosy, findings observed were similar to those of simple lymphadenitis, while in tuberous leprosy fatty infiltration is interpreted as a chief histological change. Fatty infiltration is consisted by the so-called foamy cells derived from the reticulum system.In the lesions with giant vacuoles and foreign body giant cells, fatty tissue debris from the skin or the peripheral nerves are carried through the lymph stream and caught by the lymphnodes of the filter activity, the reticuloendothelial system and the foreign body giant cells with strong phagocytic ability accumulate fatty substances. Fatty infiltration is recognized most intense in the superficial lymph nodes, especially in the inguinal nodes, becomes weaker in the profound nodes and no sign of it in the visceral nodes.But the lymph nodes of the liver port and pylorus present fatty infiltration. In the case after erythema nodosum leprosum remarkable necrosis was observed in the liver port.In macular and neural leprosy no appreciable change was observed in the lymphoid tissues.Foamy cells appeared in the lymph follicles of the spleen in tuberous leprosy, but other tissues presented no change. The result of bacillus research by the fluorescence microscope was extremely low. In general, bacilli were recognized in a small number as brilliant granules in the cells with dull fluorescence (a kind of foamy cells).

The mice were divided into two groups, each group being composed of the control groups and the treated ones. Preparation of an oil-in-water-in-oil-in-water emulsion : 0.1 mg. of E. Coli-12 cells was freezed and dried and 10 % Emazol-liquid-paraffin was at once added to them until it was easily dispersed and penetrated thoroughy of itself in them and then the water was added as shown in Table 1 and Table 2. The above-made mixture was heated in warm water less than 50*. and it was diluted 1500 fold or 4000 fold (referred to A-emulsion). The A-emulsion was kept at 4* until use. It had a characteristic feature that it was