The classical method for evaluating the waveguide ability only focuses on the optical loss coefficient. However, for the micro- or submicroscale, an organic waveguide is demonstrated by the present study whose scale effect should not be neglected. We found that the optical loss coefficient increased remarkably when decreasing the sectional size of the microfibers. Furthermore, simulations based on Finite-Difference Time-Domain also demonstrated the size-dependent effect of the waveguide. Both the experimental and simulating results showed that the optical loss coefficient converges to a certain value, which means that the scale effect can be neglected as the sectional size is large enough. On the basis of the present study, we suggest that the scale-dependent effect on the sectional size of the waveguide should be investigated by evaluating the waveguide ability by the optical loss coefficient.

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Herein, we report the synthesis methodology and anticancer evaluation of 15 compounds using copper(I)- catalyzed azide alkyne cycloaddition (CuAAC) to develop a library of saccharin-1,2,3-triazole hybrid molecules. All library compounds showed interactions with various amino acids via the basic sulphonamide and amide linkage of the parental saccharin core motif. Molecular docking studies indicated that alternative positions of saccharin-1,2,3-triazole hybrid molecules added a diversity to the potential hydrogen bonding interactions of these compounds with various amino acids. Present results revealed that hybrid derivatives of saccharin which was prepared from saccharin azide was high yield using CuAAC approach. The compounds showed a moderate anti-cancer activity against SK-OV-3 ovarian cancer cell line and could be considered for the development of potential anticancer drugs based on these new molecules.

Background: A 3D-QSAR study based on CoMFA and CoMSIA was performed on these pyrazole-pyrimidine derivatives to correlate their chemical structures with the observed activity against M. tuberculosis. Objective: The current research aimed to synthesize and evaluateed pyrazole-pyrimidine based antitubercular agents by an in vitro microbial study based on our previously reported 3D-QSAR. Methods: The designed molecules were synthesised via chalcone intermediate and cyclisation using guanidine and urea. The molecules were then characterized by various spectroscopic methods like IR, MASS, 1H-NMR, 13C-NMR and in vitro evaluation against M. tuberculosis H37Rv. They were further evaluated under anaerobic condition and their intracellular assay was studied. The compounds were further examined for cytotoxicity towards eukaryotic cells. Results: Compounds 3a, 3c and 3i were found to be the most effective against M. tuberculosis H37Rv, with IC50 of 16μM, 13μM and 15μM, respectively. Conclusion: The designed strategy, to enhance the antitubercular activity against M. tuberculosis H37Rv, was proved fruitful. On considering the overall data, the promising results would be useful to design the next target with improved efficacy and potency of compounds for further medicinal importance.