The classical method for evaluating the waveguide ability only focuses on the optical loss coefficient. However, for the micro- or submicroscale, an organic waveguide is demonstrated by the present study whose scale effect should not be neglected. We found that the optical loss coefficient increased remarkably when decreasing the sectional size of the microfibers. Furthermore, simulations based on Finite-Difference Time-Domain also demonstrated the size-dependent effect of the waveguide. Both the experimental and simulating results showed that the optical loss coefficient converges to a certain value, which means that the scale effect can be neglected as the sectional size is large enough. On the basis of the present study, we suggest that the scale-dependent effect on the sectional size of the waveguide should be investigated by evaluating the waveguide ability by the optical loss coefficient.

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Herein, we report the synthesis methodology and anticancer evaluation of 15 compounds using copper(I)- catalyzed azide alkyne cycloaddition (CuAAC) to develop a library of saccharin-1,2,3-triazole hybrid molecules. All library compounds showed interactions with various amino acids via the basic sulphonamide and amide linkage of the parental saccharin core motif. Molecular docking studies indicated that alternative positions of saccharin-1,2,3-triazole hybrid molecules added a diversity to the potential hydrogen bonding interactions of these compounds with various amino acids. Present results revealed that hybrid derivatives of saccharin which was prepared from saccharin azide was high yield using CuAAC approach. The compounds showed a moderate anti-cancer activity against SK-OV-3 ovarian cancer cell line and could be considered for the development of potential anticancer drugs based on these new molecules.