The purpose of this study was to observe the change in double product with increases in the intensity of bicycle exercise. Eleven young male adults participated in this study. The subjects performed graded bicycling exercise increasing 20 watts every 2 min from 0 watts until the heart rate (HR) reached 170 beats · min Ϫ1 . During exercise systolic blood pressure (SBP) and HR were continuously measured. Initially SBP gradually increased with the increase in workload, but when the intensity of exercise became even higher, the rate of increase slowed. On the other hand, the increase in HR was very small during the initial 5 min of exercise and when the intensity of exercise increased, the rate of increase of HR became higher. The polygonal regression analyses on the relation of double product to elapsed time revealed clear break-points. On average, the break-point of double product was 6.6 min (56 watts). These results clearly showed that the break-point of double product with an increase in workload appeared even though the workload was relatively low.

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Background: Bronchial contraction and dilation is thought to be caused by non-adrenergic non-cholinergic nerves. Objective: To investigate the effects of low-frequency (1-5 Hz) and high frequency (50-100 Hz) electric acupuncture (EA) stimulation on bronchial dilation. Design: Prospective, single-center study. Setting: Teikyo Heisei University Subjects: Seventeen healthy male adults Randomization: We randomly assigned subjects to 2-Hz EA and 100-Hz EA groups in a crossover trial. The washout period was 2 weeks. Intervention: Both groups underwent a respiratory function test, followed by a 5-minute rest, followed a 5-minute rest or EA stimulation, followed by a 5- min rest. Heart rate variability was measured at rest, followed by another respiratory function test. Acupuncture was delivered near the cervical ganglia at the level of the sixth cervical vertebra on the left side. EA stimuli were set to 2-Hz or 100-Hz, and stimulation intensity was set to a level where no pain was felt. Main outcome measures: Spirometry (forced vital capacity, forced expiratory volume in 1 s, and maximum respiratory flow), autonomic nerve activity (low-frequency component, high-frequency component, and their ratio), and heart rate variability. Results: Heart rate variability analysis showed significant differences in heart rate between the 2-Hz EA and 100-Hz EA groups. The 2-Hz EA group showed a significant increase in HF. Conclusions: 2-Hz EA stimulation resulted in decreased heart rate and increased HF during stimulation. This may be more effective for regulation of the autonomic nerves of the cardiopulmonary system than 100-Hz EA stimulation. Future studies are required to confirm our findings.