Between 1991 and 1994, at Hoshigaoka Koseinenkin Hospital, we treated 280 patients with chronic hepatitis C with interferon (IFN), and ischemic colitis occurred in two patients (0.7%) during the treatment. Melena appeared in case 1 in the 2nd month after the initiation of IFN-alpha treatment, and in case 2 in the 6th month. In both patients, longitudinal ulcerations in the descending colon were revealed by urgent colonoscopy, and these resolved within 2 weeks after discontinuation of the IFN treatment. It appears that ischemic colitis was associated with the IFN treatment, suggesting that attention should be paid to this possible complication.

We divided the erosive gastritis into two types, namely, the mature type and the immature type. The mucosal elevation consisted of fibrosis in the former type and of edema in the latter. The surrounding mucosal elevation is irreversible in the erosive gastritis of mature type, on the contrary, it is reversible in the immature type. It is difficult to differentiate these two types, however, it is possible by the repeated examination. The frequency rate of the erosive gastritis is hard to evaluate, however, taking into consideration the factors, gastric juice, allergic reaction, and auto-immune mechanism for the development of the erosive gastritis; we must think over the "Erosion". The frequency rate of the erosive gastritis is high in the case of gastric and duodenal ulcer, the differentiation of the erosive gastritis from the flat erosion will be greatly suggestive for the diagnosis and treatment of the ulcerative lesion.Endoscopy 3 (1970) 168-174

The application of the indirect dye scattering method, which was invented by us, is of great help to obtain the correct endoscopical diagnosis, and also make it possible to discriminate between the fundic and the pyloric gland areas.-2. The mucosae of the two areas revealed the different fine structures respectively.-3. The endoscopical glandular border is displaced to the oral side and the pyloric gland area becomes more extensive with aging. Many of the cases with active ulcer have a small pyloric gland areas and many of the cases with ulcer-scar and gastric polyp have extensive ones.-4. The recognition of the fundic and the pyloric gland areas will make a great contribution to the diagnosis, the progress and the pathophysiology of various kinds of gastric diseases in the future.

There are some discussions for the definition and classification of the early carcinoma of the stomach. However, experiencing more cases and facilitating discussions, we are promoting our diagnostic ability and improving the prognosis of the gastric cancer. The Japanese definition and classification of "The early carcinoma of stomach" is still fully acceptable four our mutual and international understandings of gastric carcinoma.

The analysis of 87 cases of early gastric cancers does not demonstrate significant differences from findings which are reported in the Japanese literatur, above all as far as the macroscopic types, the histological pattern and the topographic distribution is concerned. The frequency of that diagnose during the fourth and fifth decade of the patients is hereby remarkable. The first biopsy allowed the diagnose of a carcinoma in the majority of all cases. The number of diagnosis of early gastric cancer increases together with the growing amount of gastric-bioptical examinations.Key-Words: Early gastric cancer, frequency and types of early gastric cancer, early gastric cancer in Germany.Reporting on our experience with early gastric carcinoma in Germany I have to stress that I acquired the knowledge on this subject in Japan. When I studied during a visit to Japan in spring 1970 the large number and the many aspects of early gastric cancer I thought that I was dealing with a "national Japanese carcinoma". Of course, we knew the description of mucosal carciEndoscopy 7 (1975) 5-10