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Deficiency of vitamin D is an important cause of osteosarcopenia. The purpose of this study is to examine the effects of low energy narrow-range UV-LED on osteosarcopenia in animal models of senescence-accelerated mouse prone 6 (SAMP6). Preliminary experiments specified the minimum irradiance intensity and dose efficacy for vitamin D production (316 nm, 0.16 mW/cm 2 , 1,000 J/m 2 ). we set a total of 4 groups (n = 8 per group); vitamin D-repletion without UV irradiation (Vit.D+UV−), vitamin D-repletion with UV irradiation (Vit.D+UV +), vitamin D-deficiency without UV irradiation, (Vit.D−UV−), and vitamin D-deficiency with UV irradiation (Vit.D−UV +). Serum levels of 25(OH)D at 28 and 36 weeks of age were increased in Vit.D−UV+ group as compared with Vit.D−UV− group. Trabecular bone mineral density on micro-CT was higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. In the histological assay, fewer osteoclasts were observed in Vit.D−UV+ group than in Vit.D−UV− group. Grip strength and muscle mass were higher in Vit.D−UV+ group than in Vit.D−UV− group at 36 weeks of age. Signs of severe damage induced by UV irradiation was not found in skin histology. Low energy narrow-range UV irradiation may improve osteosarcopenia associated with vitamin D deficiency in SAMP6.

The functional outcomes, implant survival, and rate of complications for cementless THAs are comparable at a mean follow-up of ten years for ONFH and OA.

This study investigated effects of narrow-range ultraviolet irradiation (UVR) by a new UV-LED device on vitamin D supply and changes of bone in senescence-accelerated mouse P6 (SAMP6) with vitamin D deficiency. Main methods: We used female SAMP6 mice as a senile osteoporotic model. We set a total of 3 groups (n ¼ 4 per group); D-UVRþ group (vitamin D deficient-dietary and UVR), D-(vitamin D deficient-dietary), and Dþ groups (vitamin D contained-dietary). Mice in the D-UVR þ group were UV-irradiated (305nm) with 1 kJ/m 2 twice a week for 12 weeks from 20 to 32 weeks of age. Serum 25(OH)D, 1,25(OH) 2 D, and micro-computed tomography (CT) were assessed over time. Mechanical test, and histological assay were performed for femurs removed at 32 weeks of age. Key findings: UVR increased both serum 25(OH)D and 1,25(OH) 2 D levels at 4 and 8 weeks-UVR in the D-UVRþ group compared with that in the D-group (P < 0.05, respectively). Relative levels of trabecular bone mineral density in micro-CT were higher in the D-UVRþ group than in the D-group at 8 weeks-UVR (P ¼ 0.048). The ultimate load was significantly higher in the D-UVRþ group than in the D-group (P ¼ 0.036). In histological assay, fewer osteoclasts and less immature bone (/mature bone) could be observed in the D-UVRþ group than in the D-group, significantly. Significance: UVR may have possibility to improve bone metabolism associated with vitamin D deficiency in SAMP6 mice.