Background: Rabies, a viral disease that affects all warm-blooded animals, is widespread in many regions of the world. Human rabies, transmitted by dogs is an important public health issue in Ethiopia. To-date, effective rabies control program still remains to be a reality and needs to be strengthened.. Conclusion:The recorded data showed the underestimate of rabies diagnosis, post exposure prophylaxis and fatal human cases, which could be attributed due to the absence of national rabies surveillance system. Therefore, It is of paramount importance to assess and map the national picture of rabies within a given time interval to launch a national rabies control strategy. [Ethiop. J. Health Dev. 2010;24(2):127-132]

A retrospective data on the number of confirmed animal rabies cases and applied rabies control measures over the period 2003-2009 were collected and analyzed to elucidate the situation of animal rabies in and around Addis Ababa. Over the last seven years, 2517 animals brain tissue samples from Dogs, Cats, Cattle, Horses, Donkeys, Shoats, Hyenas and Monkeys were examined for rabies using Fluorescent Antibody Test. Out of all samples examined, 76.9% (n=1936) were positive for rabies antigen. A statistically significant difference (χ 2 = 34.08(1), P<0.0001) in sample positivity was observed between male and female dogs, which seems higher proportion in males 79.2% as compared to 66.9% in females. Higher proportions of cases were confirmed in stray (86.3%) than owned dogs (73.5%). The difference was highly significant (χ 2 = 34.79(1), P<0.0001).There was highly significant difference (χ 2 = 46.73(1), P< 0.0001) in positivity on the vaccination status of dogs. The annual vaccination coverage varies from 1.8-3.8% during the last seven years. The annual confirmed number of rabies cases dropped in 2005 and 2007 during the last seven years rabies trend in and around Addis Ababa. Statistically significant difference was observed (F=11.65, P< 0.0001) in mean number of confirmed rabies cases among 12 calendar months, more number of animal rabies cases was confirmed in summer season.

A study was conducted between November, 2007 and April, 2008 to evaluate the anti-rabies activity of the leaf of Salix subserrata and root of Silene macroselen which are traditionally used for the treatment of rabies in Bereh-Aleltu Woreda, North Shewa, Central Ethiopia. The study involved oral administration of crude extracts of Salix subserrata and Silene macroselen to Pasteur Virus (PV) strain rabies virus infected mice which were assigned into three treatment and one negative control groups. Chloroform, methanol 80% and aqueous extracts of the study plants were prepared using maceration technique. Statistical analysis was performed by one-way analysis of variance tests coupled to least significant difference to compare result between treatment and positive control groups. Of the 6 crude extracts, chloroform and methanol 80% of Silene macroselen and chloroform and aqueous of Salix subserrata were found to increase the survival time of mice significantly (P< 0.05). Nevertheless, aqueous extract of Silene macroselen and methanol 80% extract of Salix subserrata did not exhibit a significant effect on the survival time. 1 day and 2 days treatment groups of the chloroform extract of S. macroselen indicated significant difference on the survival time from the positive control (P< 0.05). The chloroform and aqueous extracts of S. subserrata and the methanol 80 % extract of S. macroselen in their 1 day and 3 days treatment showed significant difference on survival time from the positive control group (P< 0.05). The results obtained from the present work suggest good correlation between traditional therapeutic uses and the in vivo anti-rabies activity. Further characterization of the active ingredients would reveal useful compounds.

Introduction: Animal bites and scratches represent the most important public health issue related to dogs and cats because of the risk of rabies transmission associated with physical, psychological trauma and wound infection. Objective: The study was aimed at estimating the prevalence of animal bite of human beings in Addis Ababa. Methods: Data on the kind of animal, age of the patients, gender, site of bites and /or scratch were collected from the registry book and analyzed using SPSS version 11.5. Results: A total of 1299 cases of bite and/or scratch were reported for the period September 2008 to August 2009. The majority of bites were made by dogs where stray dogs are much higher (X 2 = 0.83, p= 0.36). There is statistically highly significant difference of bites between sex (p = 0.001) and between age group (F = 5.41, p=0.02). The animal bite made by dogs was higher on legs (55.6 %) followed by hands (26.45 %) and multiple bites (7.51 %). Conclusions:The majority of bites were attributed to stray dogs followed by cats, horses, donkeys. To reduce the problem a preventative public education is suggested. [Ethiop. J. Health Dev. 2011;25(1):58-60]