The implementation of cisplatin-based
neoadjuvant chemotherapy
(NAC) plays a key role in conjunction with surgical resection in preventing
bladder cancer progression and recurrence. However, the significant
dose-dependent toxic side effects of NAC are still a major challenge.
To solve this problem, we developed a photoenhanced cancer chemotherapy
(PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate),
which is abbreviated as BITT. Multifunctional BITT@BSA–DSP
nanoparticles (NPs) were employed with an albumin-based nanocarrier
decorated with the cisplatin(IV) prodrug and loaded to produce strong
near-infrared fluorescence imaging (NIR FLI), and they exhibited good
photoenhancement performance via photodynamic therapy (PDT)
and photothermal therapy (PTT). In vitro results
demonstrated that BITT@BSA–DSP NPs could be efficiently taken
up by bladder cancer cells and reduced to release Pt (II) under reductase,
ensuring the chemotherapy effect. Furthermore, both in vitro and in vivo evaluation verified that the integration
of NIR FL imaging-guided PECC efficiently promoted the sensitivity
of bladder cancer to cisplatin chemotherapy with negligible side effects.
This work provides a promising strategy to enhance the sensitivity
of multiple cancers to chemotherapy drugs and even achieve effective
treatments for drug-resistant cancers.
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