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The first total synthesis of dragmacidin A has been accomplished using condensation of two indolylglycines followed by cyclization and reduction. The general and practical method for synthesis of indolylglycines via Wittig reaction, azide addition, and reduction from indolin-3-ones is also described.

A new tris-guanidine alkaloid, KB343 (1), was isolated from the aqueous extract of a Palauan zoantharian, Epizoanthus illoricatus. The structure of 1 was determined on the basis of spectral analyses of 1 and its derivatives. The absolute configuration for 1 was determined upon comparison of the CD spectrum of 1 to those obtained from density functional theory calculations. The structure of 1 is highly unusual, as three guanidine groups are present in one ring system.

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