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Alkaloids U 0600 Total Synthesis of Marine Bisindole Alkaloid (+)-cis-Dihydrohamacanthin B. -(HIGUCHI, K.; TAKEI, R.; KOUKO, T.; KAWASAKI*, T.; Synthesis 2007, 5, 669-674; Meiji Pharm. Univ., Kiyose, Tokyo 204, Japan; Eng.) -Mais 28-179

We studied the selective formation of 3,5-and 2,5-pyrazinone via a transamidation-cyclization reaction. The equilibrium between acyl amides changed depending on the solvent, acidity, and substituents. Furthermore, selective transformation of 2,5-pyrazinone was accomplished by using a substrate with a secondary amine.Hydrogen ion exponent (pH) was measured on a Horiba F-13 and electrode was used with Horiba 9677-10D. N-( -Oxoacetyl diamines 1 were prepared according to our previously reported procedure. 8

Indole derivatives R 0140Novel Synthesis of Optically Pure Indolylglycinols Using Lipase-Mediated Resolution. -A preparative method for optically active title compounds, required as intermediates for alkaloids and pharmaceutical agents, is based on the lipase PS-mediated kinetic resolution of the corresponding azido acetates (IV). -(KOUKO, T.; KOBAYASHI, J.-I.; OHTA, A.; SAKAMOTO, M.; KAWASAKI*, T.; Synthesis 2004, 15, 2463-2470; Meiji Pharm. Univ., Kiyose, Tokyo 204, Japan; Eng.) -Mais 11-133