Primary mouse cells transformed by adenovirus type 12 (Adl2) expressed negligible amounts of class I antigens H-2K, -D, and -L on the cell surface and were capable of forming tumors in syngeneic animals, whereas cells transformed by Ad5 continued to express class I antigens and were nontumorigenic.

Canine COX-2 was selectively inhibited by etodolac, nimesulide, and NS398; tolfenamic acid and carprofen also appeared to be preferential COX-2 inhibitors in dogs. The roles of COX-1 as a constitutive housekeeping enzyme and COX-2 as a proinflammatory inducible enzyme (as determined in humans) appear to apply to dogs; therefore, COX-2-selective inhibitors should prove useful in reducing the adverse effects associated with nonselective NSAIDs.

The adenovirus type 12 (Adl2) early region

No abstract

EMBL accession no. X13722 A 4.7 kb cDNA clone (ArLDL2-1a) coding for the rat low density lipoprotein (LDL) receptor was isolated from a Xgt-11 rat liver cDNA library (1,2). The DNA sequence of the entire coding region and portions of the 5' and 3' untranslated region is shown in Figure 1. The open reading frame coded for an 879 amino acid polypeptide with a theoretical molecular weight of 96,632, which is larger than the size of the human (3) and rabbit (4) LDL receptors. A signal sequence of 21 amino acids was also present in both the rat (Fig. 1) and human (3) receptors.