Shame is consistently associated with poor adjustment (e.g., depressive symptoms) among community samples but, surprisingly, has rarely been directly examined among people living with HIV/AIDS (PLWH). This limited research on shame is likely due, in part, to shame’s having been subsumed within measures of internalized stigma, an imprecise construct with varied definitions in the HIV literature. The current review summarizes research directly examining the correlates of shame among PLWH. Findings indicate that shame is associated with greater depressive symptoms, less healthcare utilization, and poorer physical health among PLWH. Directions for future research examining shame among PLWH are highlighted, including the need for more prospective research examining shame as a predictor of future adjustment.

Background: Though a largely preventable disease, liver cancer is now the fastest-increasing cause of cancer death in the US, and it is highly fatal. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it disproportionally affect racial/ethnic minorities, especially the medically underserved. Most HCC cases are associated with hepatitis B virus (HBV) and hepatitis C virus (HCV). Methods: To increase awareness of liver cancer prevention and screening, we partnered with community-based organizations through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core, in the greater Philadelphia metropolitan and New York City to design and conduct a liver cancer prevention project. Pre- and post- survey data was collected from underserved Asian, African, and Hispanic American community members who participated in educational workshops. This abstract will report the 473 eligible participants' knowledge on HBV, HCV, and liver cancer both before and after the education. We conducted wilcoxon Signed-rank, Kruskal-Wallis, and Wilcoxon sum-rank tests. Results: Knowledge of risk factors increased significantly in all three communities from the pre-survey to the post-intervention survey (2.15 vs. 3.69, p<0.0001). Knowledge of risk factors also significantly increased within the African (1.11, p<0.0001), Asian (1.88, p<0.0001) and Hispanic (3.21, p<0.0001) American Communities. There were no significant differences in increased knowledge by gender (male= 2.18 vs female=2.25, p=0.72). Conclusions: The findings of our study show the importance and effectiveness educational interventions have on promoting liver cancer prevention knowledge among the minority groups who are most affected in the U.S. by liver cancer disparity. Citation Format: Wenyue Lu, Lin Zhu, Safa Ibrahim, Kerry Traub, Ellen Kim, Ada Wong, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. Increasing liver cancer prevention knowledge through a community-based education initiative to improve liver cancer prevention for underserved African, Asian, and Hispanic communities [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-058.

Background: Liver cancer increased 72 percent between 2003 and 2012 in the US. Similarly, the liver cancer death rates in the US are increasing faster than for any other cancer, having doubled since the mid-1980s. People with hepatitis B and C have the greatest risk of liver cancer. In the US, approximately 65 percent of liver cancer cases are related to hepatitis B or C (HBV or HCV), with nearly 50 percent attributable to hepatitis C alone. Objective: The Community Outreach Core (COC) Program is a part of the NCI funded TUFCCC/HC Regional Cancer Health Partnership Program and targets areas of Pennsylvania, New Jersey, and New York City. One of the most important goals of the COC is engaging community partners in cancer outreach research to reduce cancer disparities among underserved minority populations in the Partnership targeted geographic areas using Community-Based Participatory Research (CBPR) approaches.The purpose of this project is to mobilize the community to increase awareness of hepatitis B and C, and empower community members to talk to their trusted doctors about hepatitis B and C and to be tested. Method: The campaign features an educational advertisement on SEPTA buses (Southeastern Pennsylvania Transportation Authority) in Philadelphia City, PA. The promotional messages included culturally tailored educational messages targeting high risk residents with HBV or HCV related liver disease. The central message of the ad calls for action of “getting screened for HBV and HCV”. The Campaign ad poster (21”x22”) posted in 115 buses traveling in the City of Philadelphia for 4 weeks. In total, 938,280 bus riders had a chance to view the ad information. 173 survey forms were collected from diverse racial/ethnicity bus riders both men and women during the campaign period. Results: Among the 173 respondents, 22.7% of them reported “saw advertisement on the bus.” Specifically, riders who saw the advertisement are significantly more likely to get screened for HBV/HCV than those who did not see the advertisement (86.5% vs 58.3%). Conclusion: The findings of the project suggested that culturally tailored educational messages can effectively promoting HBV/HCV screening. The next steps of community outreach strategies will also be discussed. Citation Format: Kerry L Traub, Jean Marie Kouassi, Evelyn González, Elizabeth Yi, Safa Ibrahim, Wenyue Lu, Yin Tan, Ming-Chin Yeh, Olorunseun O Ogunwobi, Marilyn A Fraser. Reducing liver cancer disparities through culturally tailored educational messages: A city-wide bus campaign in Philadelphia City [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B027.

Background: There is an increasing body of literature that suggests a relationship between modifiable dietary behaviors and alcohol use and liver cancer. We designed and implemented a culturally tailored community-based education program to promote liver cancer prevention. Methods: Through NCI funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core program, using CBPR approach, we engaged community-based organizations and community stakeholders serving underserved African, Asian, and Hispanic American communities in the Philadelphia metropolitan area and New York City. The community-based education incorporated in-person and virtual hybrid education workshops to address COVID-19 pandemic barriers. We conducted pre-education surveys and follow-up assessments at 6 months post-education. Participants' dietary behaviors, alcohol use, and sociodemographic characteristics were examined at both time points. Results: 526 participants were recruited including 92 African Americans, 247 Asian Americans, and 187 Hispanic Americans, with an average age of 59. We found that at 6-month follow-up assessment, participants had average decreased intake of red meat (3.148/6 vs. 2.685/6, p < 0.001), and average increased intake of vegetables (4.484/6 vs. 5.044/6, p < 0.001) and fruits (4.327/6 vs. 4.877/6, p < 0.001), compared to their intake at pre-education assessment. Additionally, average change in beer (-0.252) and spirit (-0.905) consumption substantively decreased from pre-intervention to 6-month follow-up assessment. Conclusion: This community-based education showed significant effects in improving healthy dietary behaviors and reducing alcohol intake among community members through CBPR community engagement from the two metropolitan areas. Future efforts are needed to sustain the positive changes in modifiable lifestyle behaviors and liver cancer prevention in these medically underserved communities. Citation Format: Tiffany Li, Wenyue Lu, Lin Zhu, Ellen Kim, Kerry Traub, Steven Zhu, Nathaly Rubio-Torio, Evelyn Gonzalez, Marilyn A. Fraser, Ming-Chin Yeh, Grace X. Ma, Olorunseun O. Ogunwobi, Yin Tan. A community-based liver cancer education initiative led to healthier dietary and alcohol use behaviors among racial/ethnic minority community members [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-161.