A B S T R A C TFertility is one of the three principal components of population dynamics that determine the size, structure, and composition of the population in any country. Children ever born refer to the number of children born alive to the person up to a specified reference date. It includes children who have died since birth. This study aims to identify the socioeconomic and demographic factors influencing Children Ever Born (CEB) to the women of Somadi village development committee (VDC) of Palpa district of Nepal. This study is entirely based on primary data collected using convenience sampling through questionnaire methods. A representative sample of size 298 married women was taken for the study using proportionate sampling from the different ethnic groups. The result of the study shows that the factors age at marriage, occupation of husband and knowledge of contraceptive/family planning have statistically significant role for varying CEB among the women under study. The result of the study compels to recommend that various awareness programs should be conducted about the use of contraceptive/family planning and to stop practice of early marriage among the women to reduce the higher fertility. The factors 'knowledge of contraceptive/family planning', 'occupation of husband' and 'age at marriage' are seen to have very significant impact for explaining the children ever born (CEB) to the women of Somadi VDC of Palpa district of Nepal.

Background: The clavicle, modified long bone, presents morphological and bilateral variations. This may be due to genetic factors, hormones, or environmental and occupational influences. Anthropometric studies in clavicle of Nepalese population using radiograph has not been reported to best of our knowledge. This study, aimed to determine the sexual dimorphism and bilateral asymmetry of clavicle in Nepalese Population using Postero-Anterior Chest X Ray. Methods: Chest x-rays with normal and clearly visible both clavicles of 1260 Nepalese adults (591 male, 669 female), aged above 20 years were utilized. Inbuilt software “Computed Radiography Fuji Computer System 7” was used for measurements (in centimeter) of sternal head length, acromial end length, mid shaft diameter and length of clavicle. Demarcating point and identification point were calculated. Patients having history of clavicles fractures in the past were excluded. Results:  All the parameters in male is greater than female which is significant except Length/Mid Shaft Diameter. Similarly, all the parameters of right clavicle is significantly greater than left clavicle in both sexes except Sternal Head Length and Mid Shaft Diameter. Demarcating point calculated from length of the clavicle (right >16.17, left >16.10 for male and right <11.20, left <10.65 for female) and Mid Shaft Diameter (right >1.33, left >1.38 for male and right <0.66 and left <0.67 for female) are important parameters to determine sex.    Conclusions:The clavicle shows significant sexual dimorphism and bilateral asymmetry in Nepalese population. The result of this study is helpful to anthropologist and forensic medicine. Keywords: Anthropometry; clavicle; demarcating point; postero-Anterior chest x-rays; sexual dimorphism

Sikkim, India, has the highest proportion of tuberculosis (TB) patients on first-line anti-tuberculosis regimens with the outcome 'failure' or 'shifted to regimen for multidrug-resistant TB (MDR-TB)'. Objective: To assess the factors associated with non-response to treatment, i.e., 'failure' or 'shifted to MDR-TB regimen'. Methods: We conducted a retrospective cohort study using Revised National Tuberculosis Control Programme data of all TB patients registered in 2015 for first-line TB treatment. In addition, we interviewed 42 patients who had not responded to treatment to ascertain their current status. Results: Of 1508 patients enrolled for treatment, about 9% were classified as non-response to treatment. Patient factors associated with non-response were urban setting (adjusted odds ratio [aOR] 2.39, 95%CI 1.22-4.67), ethnicity (being an Indian tribal, aOR 1.73, 95%CI 1.17-2.57, Indian [other] aOR 1.83, 95%CI 1.29-2.60 compared to patients of Nepali origin) and those on retreatment (aOR 2.40, 95%CI 1.99-2.91). Of the patients interviewed, 28 (67%) had received treatment for drug-resistant TB. Conclusion: In Sikkim, one in 11 patients had not responded to first-line anti-tuberculosis treatment. Host-pathogen genetics and socio-behavioural studies may be required to understand the reasons for the differences in non-response, particularly among ethnic groups. * Data for 26 patients were not available and were therefore not included in the table. RNTCP = Revised National Tuberculosis Control Programme; TB = tuberculosis; MDR-TB = multidrug-resistant TB.

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Introduction: Age-related physiological changes predispose older road users to higher mortality from traffic crashes. We aimed to describe the injury epidemiology of these patients, and explore the association between the comorbidity polypharmacy score (CPS) and outcomes. Materials and Methods: This retrospective study utilised data from the Trauma Registry in the National University Hospital, Singapore, between January 2011 and December 2014. Patients involved in traffic crashes aged 45 years and above with injury severity scores (ISS) of 9 and higher were included. Results: There were 432 patients; median age was 58 (interquartile range, 51 to 65.5) years with predominance of male patients (82.2%) and Chinese ethnicity (66%). Overall mortality was 9.95%, with lower odds associated with higher Glasgow Coma Scale (odds ratio [OR] 0.73; 95% confidence interval [CI], 0.65 to 0.81, P <0.001), higher diastolic blood pressure (OR 0.98; 95% CI, 0.97 to 1.00, P = 0.031), and lower ISS of 9 to 15 (OR 0.10; 95% CI, 0.02 to 0.43, P = 0.002). The need for blood products was associated with higher mortality (OR 7.62; 95% CI, 2.67 to 21.7, P <0.001). CPS did not predict mortality. Independent predictors of discharge venue included length of stay, tier of injury and CPS group. Moderate CPS was statistically significant for nursing home placement (OR 10.7; 95% CI, 2.33 to 49.6, P = 0.002) but not for rehabilitation facility. Conclusion: CPS score is useful in predicting discharge to a nursing home facility for older patients with traffic crashes. Further larger studies involving other trauma types in the Asian population are needed to evaluate its utility. Key words: Elderly, Motor vehicle crashes, Trauma severity indices