Stir bar sorptive extraction (SBSE) coupled with gas chromatography/mass spectrometry (GC/MS) was used to analyse wine samples for three applications: flavour and compositional analysis; 2,4,6-trichloroanisole (TCA), a common off-aroma in wine; and agrochemicals. SBSE was found to be orders of magnitude more sensitive than modern conventional methodology, allowing for lower detection and quantitation levels, and improved confirmation of identity; SBSE often gave better signal to noise in scan mode than other methods in selective ion monitoring (SIM) mode. With the help of their characteristic mass spectra all agrochemicals could be identified unambiguously at concentrations of 10 microg L(-1) in wine and a further 100 constituents were detected in a Cabernet Sauvignon sample. Thus it is now possible to analyse complex samples such as wine by scan mode, with better confirmation of identity, and without sacrificing sensitivity, where previously SIM methodology had to be used.

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Abstract. Adsorptive accumulation in stripping voltammetry has been applied for trace measurements of the cancerostatic drug actinomycin-C1 (ACT). Accumulation is achieved by controlled adsorption of ACT film on the hanging mercury drop electrode (HMDE). The cathodic stripping response was evaluated with respect to accumulation time, concentration dependence, solution conditions and other variables. The limit of detection after 5 minutes preconcentration is 1 µg L −1 (8 × l0 −10 M). The effects of possible interferences, due to coexisting metal ions or organic substances, are evaluated. The applicability of the method to the determination of ACT in untreated urine is described.

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