The thymidine analog fialuridine [1-(2-deoxy-2-fluoro-P3-D-arabinofuranosyl)-5-iodouracil (FIAU)] was toxic in trials for chronic hepatitis B infection. One mechanism postulated that defective mtDNA replication was mediated through inhibition of DNA polymerase-y (DNA pol-y) by FIAU triphosphate (FIAUTP)
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