Background/Aims: Mediterranean diet, owing to its inflammation-modulatory effects, is considered a beneficial dietary regimen for patients with inflammatory bowel disease. Despite promising results in the literature, studies on this subject are still limited. Therefore, the aim of this study was to evaluate adherence to the Mediterranean diet in patients with inflammatory bowel disease and examine its impact on disease activity and quality of life. Materials and Methods: A total of 83 patients were included in the study. Mediterranean Diet Adherence Scale was used to evaluate adherence to the Mediterranean diet. Crohn’s Disease Activity Index was used to evaluate disease activity in Crohn’s disease. Disease activity was determined by using the Mayo Clinic score for ulcerative colitis. Quality of Life Scale Short Form-36 was used to evaluate the quality of life of patients. Results: When the median Mediterranean Diet Adherence Scale score was 7 (1-12), only 18 patients (21.7%) showed strong adherence to the Mediterranean diet. Disease activity scores of patients with ulcerative colitis having low adherence to the Mediterranean diet were found to be higher ( P < .05). In addition, some quality of life parameters were relatively higher in patients with ulcerative colitis who showed strong adherence to the Mediterranean diet ( P < .05). For Crohn’s disease, no significant difference was found in disease activity and quality of life with respect to adherence to the Mediterranean diet ( P > .05). Conclusion: Stronger adherence to the Mediterranean diet in patients with ulcerative colitis can help improve quality of life and modulate disease activity. However, further prospective studies are needed to investigate the potential use of the Mediterranean diet in inflammatory bowel disease management.
ÖZET Polikistik over sendromu (PKOS); menstrüel düzensizlik, yükselmiş androjen seviyeleri ve polikistik görünümlü overler gibi özellikleri ile üreme çağındaki kadınlarda en sık görülen endokrinopatidir. Kalıtım, obezite, diyabet hastalığı PKOS için başlıca risk faktörlerindendir. Bununla birlikte, mevcut kanıtlar insülin direncinin PKOS patogenezinde merkezi bir role sahip olduğunu ve altta yatan metabolik anormallikleri şiddetlendiren önemli bir faktör olarak öne çıktığını göstermektedir. Gözlemsel çalışmalar D vitamini eksikliğinin de PKOS gelişiminde rol oynayabileceğini düşündürmektedir. PKOS'lu kadınlarda D vitamini eksikliği yaygın görülen bir sorundur. PKOS'lu kadınların %67-85'inin ortalama 25-hidroksi vitamin D (25OHD) düzeyleri 20 ng/mL'nin altındadır. D vitamini eksikliği özellikle obezite, hiperandrojenizm, üreme fonksiyonlarında bozukluk durumlarını daha da ağırlaştırarak PKOS gelişimine zemin hazırlayabilmektedir. Bununla birlikte yapılan çalışmalar D vitamini eksikliğinin, PKOS patogenezinde başlıca rol oynayan insülin direncinin gelişiminde önemli bir rol oynadığını ortaya çıkarmıştır. Yakın geçmişte PKOS tedavisinde D vitamini takviyesinin etkilerini değerlendiren bazı randomize kontrollü çalışmalar dâhil olmak üzere yapılan çeşitli çalışmaların sonuçları ise değişkenlik göstermektedir. Vitamin D takviyesinin PKOS yönetimi için yararlı olabileceği düşünülse de PKOS'lu kadınlarda D vitamini desteğinin insülin direnci ve diğer semptomlar üzerindeki etkileri ve bu etkilerin hangi yolaklarla sağlandığı konuları hâlâ belirsizliğini korumaktadır. Bu çalışmada, D vitamininin PKOS ve insülin direnci patogenezindeki olası etkilerini ve PKOS tedavisindeki rolünü ortaya koymak amaçlanmıştır. Anah tar Ke li me ler: D vitamini eksikliği; insülin direnci;polikistik over sendromu ABS TRACT Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age with features such as menstrual irregularity, elevated androgen levels and polycystic ovaries. Family history, obesity, diabetes are the main risk factors for PCOS. However, current evidence suggests that insulin resistance plays a central role in the pathogenesis of PCOS and appears to be an important factor that compounds underlying metabolic abnormalities. Observational studies suggest that vitamin D deficiency may also play a role in the development of PCOS. Vitamin D deficiency is a common problem in women with PCOS. 67-85% of women with PCOS have 25-hydroxy vitamin D (25OHD) levels below 20 ng/mL. Vitamin D deficiency may aggravate the conditions of obesity, hyperandrogenism and reproductive functions, and may pave the way for the development of PCOS. However, studies have shown that vitamin D deficiency plays an important role in the development of insulin resistance, which plays a major role in PCOS pathogenesis. The results of several recent studies, including some randomized controlled trials evaluating the effects of vitamin D supplementation in PCOS treatment are variable. Although vitamin D supplementation is thought ...
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