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Objective: Sperm motility is one of the most important factor in fertility of men. Because, it describes the ability of sperm to move properly through the female reproductive tract and reach the egg in order to fertilize it. Various factors, such as semen quality and other parameters are known to be effect on sperm motility. This study was designed to determine, how semen parameters and individuals age infl uence on sperm motility. Method: Samples were collected from 273 men undergoing evaluation and treatment for infertility in Infertility Treatment Center, ACECR branch of Qazvin, Qazvin, Iran. Semen analysis was performed according to World Health Organization (WHO) criteria. In this procedure we considered on determination of sample volume, sperm concentration, motility, normal morphology and liquefaction time. Results: In this analysis, our results showed, increasing in sperm count, sample volume and normal morphology increased sperm motility signifi cantly. In contrast, increasing in liquefaction time and age decreased sperm motility signifi cantly. Our statistical analysis demonstrated that sperm concentration and semen volume have the most and lowest effect on motility respectively. Conclusion: In our study, semen parameters tend to have an infl uence on sperm motility.

Neurodegenerative diseases are characterized by the progressive loss of structure or function of neurons. In this Spotlight, we explore the idea that genetic forms of neurodegenerative disorders might be rooted in neural development. Focusing on Alzheimer's, Parkinson's and Huntington's disease, we first provide a brief overview of the pathology for these diseases. Although neurodegenerative diseases are generally thought of as late-onset diseases, we discuss recent evidence promoting the notion that they might be considered neurodevelopmental disorders. With this view in mind, we consider the suitability of animal models for studying these diseases, highlighting human-specific features of human brain development. We conclude by proposing that one such feature, human-specific regulation of neurogenic time, might be key to understanding the etiology and pathophysiology of human neurodegenerative disease.