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Novel pyrimido [4,5-b]quinoline-tetraones were prepared by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, 6-amino-uracils, and aromatic aldehydes in aqueous media and catalyzed by p-toluenesulfonic acid. This protocol provides a simple one-step procedure with the advantages of easy workup, good yield of products, and environmental friendliness.

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One-Pot, Three-Component Synthesis of Pyrimido[4,5-b]quinoline-tetraone Derivatives in Water. -Easy work-up, good yields and environmentally friendliness are the advantages of the procedure. -(AZIZIAN*, J.; DELBARI, A. S.; YADOLLAHZADEH, K.; Synth. Commun. 44 (2014) 22, 3277-3286, http://dx.

In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time, having easily available-recyclable ionic liquids, and good to high yields are advantages of present method.